liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Reprogramming and Carcinogenesis-Parallels and Distinctions
Karolinska Institute, Stockholm, Sweden.
Pomeranian Medical University, Szczecin, Poland.
University of Belgrade, Serbia.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. Silesian Technical University, Gliwice, Poland.
Show others and affiliations
2014 (English)In: International Review of Cell and Molecular Biology / [ed] Kwang W Jeon, Elsevier, 2014, Vol. 308, 167-203 p.Chapter in book (Refereed)
Abstract [en]

Rapid progress made in various areas of regenerative medicine in recent years occurred both at the cellular level, with the Nobel prize-winning discovery of reprogramming (generation of induced pluripotent stem (iPS) cells) and also at the biomaterial level. The use of four transcription factors, Oct3/4, Sox2, c-Myc, and Klf4 (called commonly "Yamanaka factors") for the conversion of differentiated cells, back to the pluripotent/embryonic stage, has opened virtually endless and ethically acceptable source of stem cells for medical use. Various types of stem cells are becoming increasingly popular as starting components for the development of replacement tissues, or artificial organs. Interestingly, many of the transcription factors, key to the maintenance of stemness phenotype in various cells, are also overexpressed in cancer (stem) cells, and some of them may find the use as prognostic factors. In this review, we describe various methods of iPS creation, followed by overview of factors known to interfere with the efficiency of reprogramming. Next, we discuss similarities between cancer stem cells and various stem cell types. Final paragraphs are dedicated to interaction of biomaterials with tissues, various adverse reactions generated as a result of such interactions, and measures available, that allow for mitigation of such negative effects.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 308, 167-203 p.
, International Review of Cell and Molecular Biology, ISSN 1937-6448 ; 308
Keyword [en]
Bioglass, Senescence, Transdifferentiation, Yamanaka factor, iPS cells, p53
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-106107DOI: 10.1016/B978-0-12-800097-7.00005-1ISI: 000333378100005ISBN: 978-0-12-800097-7OAI: diva2:714172
Available from: 2014-04-25 Created: 2014-04-24 Last updated: 2014-10-08Bibliographically approved

Open Access in DiVA

fulltext(671 kB)325 downloads
File information
File name FULLTEXT01.pdfFile size 671 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textFind book in another country/Hitta boken i ett annat land

Search in DiVA

By author/editor
Cieslar-Pobuda, ArturRafat, MehrdadLos, Marek Jan
By organisation
Division of Cell BiologyFaculty of Health SciencesDepartment of Clinical and Experimental Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 325 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 176 hits
ReferencesLink to record
Permanent link

Direct link