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HIV-Mycobacterium tuberculosis co-infection: a `danger-couplemodel of disease pathogenesis
University of Malaya, Malaysia .
YRG Centre AIDS Research and Educ YRG CARE, India .
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
University of Malaya, Malaysia .
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2014 (English)In: PATHOGENS AND DISEASE, ISSN 2049-632X, Vol. 70, no 2, 110-118 p.Article, review/survey (Refereed) Published
Abstract [en]

Tuberculosis (TB) and human immunodeficiency virus (HIV) infection interfere and impact the pathogenesis phenomena of each other. Owing to atypical clinical presentations and diagnostic complications, HIV/TB co-infection continues to be a menace for healthcare providers. Although the increased access to highly active antiretroviral therapy (HAART) has led to a reduction in HIV-associated opportunistic infections and mortality, the concurrent management of HIV/TB co-infection remains a challenge owing to adverse effects, complex drug interactions, overlapping toxicities and tuberculosis -associated immune reconstitution inflammatory syndrome. Several hypotheses have been put forward for the exacerbation of tuberculosis by HIV and vice versa supported by immunological studies. Discussion on the mechanisms produced by infectious cofactors with impact on disease pathology could shed light on how to design potential interventions that could decelerate disease progression. With no vaccine for HIV and lack of an effective vaccine for tuberculosis, it is essential to design strategies against HIV–TB co-infection.

Place, publisher, year, edition, pages
Wiley / Blackwell Publishing Ltd , 2014. Vol. 70, no 2, 110-118 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-106099DOI: 10.1111/2049-632X.12108ISI: 000332771500002OAI: diva2:714194
Available from: 2014-04-25 Created: 2014-04-24 Last updated: 2014-04-25

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Ellegård, RadaLarsson, Marie
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