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Electronic control over detachment of a self-doped water-soluble conjugated polyelectrolyte
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
Department of Printed Electronics, Acreo Swedish ICT AB, Norrköping, Sweden.
Department of Printed Electronics, Acreo Swedish ICT AB, Norrköping, Sweden.
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2014 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 30, no 21, 6257-6266 p.Article in journal (Refereed) Published
Abstract [en]

Water-soluble conducting polymers are of interest to enable more versatile processing in aqueous media as well as to facilitate interactions with biomolecules. Here, we report a substituted poly(3,4-ethylenedioxythiophene) derivative (PEDOT-S:H) that is fully water-soluble and selfdoped. When electrochemically oxidizing a PEDOT-S:H thin film, the film detaches from the under-laying electrode. The oxidation of PEDOT-S:H starts with an initial phase of swelling followed by cracking before it finally disrupts and detaches from the electrode. We investigated the detachment mechanism and found that parameters such as the size, charge and concentration of ions in the electrolyte, the temperature and also the pH influence the characteristics of detachment. When oxidizing PEDOT-S:H, the positively charged polymer backbone is balanced by anions from the electrolyte solution and also by the sulphonate groups on the side chains (more self-doping). From our experiments, we conclude that detachment of the PEDOT-S:H film upon oxidation occurs in part due to swelling caused by an inflow of solvated anions and associated water, and in part due to rearrangements and strain within the film, caused by more self-doping. We believe that PEDOT-S:H detachment can be of interest in a number of different applications, including addressed and active control of the release of materials such as biomolecules and cell cultures.

Place, publisher, year, edition, pages
American Chemical Society , 2014. Vol. 30, no 21, 6257-6266 p.
National Category
Polymer Chemistry Cell Biology
URN: urn:nbn:se:liu:diva-106251DOI: 10.1021/la500693dISI: 000336952800031OAI: diva2:715025
Available from: 2014-04-30 Created: 2014-04-30 Last updated: 2015-05-28Bibliographically approved
In thesis
1. Electronic Control of Cell Cultures Using Conjugated Polymer Surfaces
Open this publication in new window or tab >>Electronic Control of Cell Cultures Using Conjugated Polymer Surfaces
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In the field of bioelectronics various electronic materials and devices are used in combination with biological systems in order to create novel applications within cell biology and medicine. A famous example of a successful bioelectronics application is the pacemaker. Metals are the most common electrical conductors, whereas polymers are generally considered being insulators. However, in the late 1970s it was shown that a special class of polymers with conjugated double bonds, could in fact, after some chemical modifications, conduct electricity. This was the start of the research field known as conducting polymers, and then later on organic electronics, a research area that has grown rapidly during the last decades. Conjugated polymers are also suitable to interact and interface with cells and tissues, as they are generally soft, flexible and biocompatible. In addition, their chemical properties can be tailor-made through synthesis to fit biological requirements and functions. During the last years applications using organic bioelectronics have become numerous.

This thesis describes applications based on different conjugated polymers aiming to stimulate and control cell cultures. When culturing cells it is of interest to be able to control events such as adhesion, spreading, proliferation, differentiation and detachment. First, the impact of different polymer compositions and redox states on the adhesion of bacteria and subsequent biofilm formation was investigated. Similar polymer electrodes were also used to steer differentiation of neural stem cells, through changes in the surface exposure of a relevant biomolecule. Controlled delivery of molecules was achieved by coating nanoporous membranes with polymers that swell and contract when changing the redox state. Finally, electronic control over cell detachment using a water-soluble polymer was achieved. When applying a positive potential to this polymer, it swells, cracks and finally detaches, taking the cells that was cultured on top along with it. Together, the work and results presented in this thesis demonstrate a versatile conjugated polymer technology to achieve electronic control of the different growth stages of cell cultures as well as cellular functions.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 64 p.
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1594
National Category
Natural Sciences
urn:nbn:se:liu:diva-106254 (URN)10.3384/diss.diva-106254 (DOI)978-91-7519-340-3 (print) (ISBN)
Public defence
2014-05-23, K2, Kåkenhus, Campus Valla, Linköpings universitet, Linköping, 10:15 (English)
Available from: 2014-04-30 Created: 2014-04-30 Last updated: 2015-05-06Bibliographically approved

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Persson, Kristin MGabrielsson, RogerKonradsson, PeterBerggren, Magnus
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