Sequence Variation and Haplotype Structure Surrounding the Flowering Time Locus FRI in Arabidopsis thaliana
2002 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 161, no 1, 289-298 p.Article in journal (Refereed) Published
Linkage disequilibrium in highly selfing organisms is expected to extend well beyond the scale of individual genes. The pattern of polymorphism in such species must thus be studied over a larger scale. We sequenced 14 short (0.5-1 kb) fragments from a 400-kb region surrounding the flowering time locus FRI in a sample of 20 accessions of Arabidopsis thaliana. The distribution of allele frequencies, as quantified by Tajima’s D, varies considerably over the region and is incompatible with a standard neutral model. The region is characterized by extensive haplotype structure, with linkage disequilibrium decaying over 250 kb. In particular, recombination is evident within 35 kb of FRI in a haplotype associated with a functionally important allele. This suggests that A. thaliana may be highly suitable for linkage disequilibrium mapping.
Place, publisher, year, edition, pages
Genetics Society of America , 2002. Vol. 161, no 1, 289-298 p.
IdentifiersURN: urn:nbn:se:liu:diva-106323ISI: 000175814900025OAI: oai:DiVA.org:liu-106323DiVA: diva2:715446