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Alternativ splicing: Mutationer i BRCA1 och BRCA2 orsakar bröstcancer
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2012 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

During the past decade it has been shown that alternative splicing is a important mechanism for the proteome diversity. AS is a mechanism that generates a large amount of protein isoforms from a low number of human genes. Alternative splicing is regulated by four groups of cis-regulatory elements and different splicing factors. Even though AS is important for the diversity and complexity of different organisms it is also a source for different genetic diseases like cancer. This review article will focus on breast cancer and its connection to the mechanism of alternative splicing. Breast cancer is a common disease in women. In recent years many studies have shown an important relationship between mutations in the alternative splicing mechanism and the two most important genes involved in breast cancer BRCA1 and BRCA2. This article will also present different efforts against this disease. 

Place, publisher, year, edition, pages
2012. , 27 p.
Keyword [sv]
Alternativ splicing, BRCA1, BRCA2, Breast Cancer, Splicing, DNMT, PARP
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-106377ISRN: LITH-IFM-G-EX--13/2721—SEOAI: diva2:715782
Subject / course
A2, Linköpings universitet 581 83, Linköping (Swedish)
Available from: 2014-06-23 Created: 2014-05-06 Last updated: 2014-06-23Bibliographically approved

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Azadi, Sahar
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Department of Physics, Chemistry and BiologyThe Institute of Technology
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