liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Optimisation of quantitative lung SPECT applied to mild COPD: a Monte Carlo-based analysis
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0002-1380-2497
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-0209-498X
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-3352-8330
Show others and affiliations
2014 (English)Manuscript (preprint) (Other academic)
Abstract [en]

The amount of inhomogeneities in a single photon emission computed tomography (SPECT) lung image, caused by reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (COPD), is correlated to disease advancement. A quantitative analysis method, the CVT-method, measuring these inhomogeneities was proposed in earlier work (Norberg et al., 2013). To detect mild COPD, which is a difficult task, optimized parameter values are needed. In this work, the CVT-method was optimized with respect to the parameter values of acquisition, reconstruction and analysis. The ordered subset expectation maximization (OSEM) algorithm was used for reconstructing the lung SPECT images. As a first step towards clinical application of the CVT-method in detecting mild COPD, this study was based on simulated SPECT images of an advanced anthropomorphic lung phantom including respiratory and cardiac motion, where the mild COPD lung had an overall ventilation reduction of 5%. The largest separation between healthy and mild COPD lung images as determined using the CVT-measure of ventilation inhomogeneity and 125 MBq 99mTc was obtained using a low-energy high-resolution collimator and a Butterworth postfilter with a cut-off frequency of 0.6-0.7 cm-1. Sixty-four reconstruction updates should be used when the whole lung is analysed and for the reduced lung a greater number of updates is needed.

Place, publisher, year, edition, pages
2014.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-106665OAI: oai:DiVA.org:liu-106665DiVA: diva2:717915
Available from: 2014-05-19 Created: 2014-05-19 Last updated: 2015-03-31Bibliographically approved
In thesis
1. Quantification and optimisation of lung ventilation SPECT images
Open this publication in new window or tab >>Quantification and optimisation of lung ventilation SPECT images
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Currently, lung function tests are the gold standard for lung function measurements. Since the outcome of a lung function test is a summation of the status of the whole lung, significant changes in lung function may occur before a deviation from the norm can be identified. A method that can reliably detect lung abnormalities earlier in a disease process would therefore be beneficial. Regional differences in the lung are ideally studied by imaging methods. Heterogeneous ventilation in lungs of allergic individuals, cigarette smokers, asthmatics and chronic obstructive pulmonary disease (COPD) patients has been demonstrated using various imaging techniques such as single photon emission computer tomography, SPECT. The amount of heterogeneous ventilation is correlated to disease advancement. The CVT-method, that measures heterogeneity using the coefficient of variation (CV) caused by lung function reduction in lung SPECT images, was developed and optimised. Lung function in patients and healthy volunteers was evaluated using the CVT-method.

Monte Carlo simulated gamma camera projections were generated of activity distributions in two anthropomorphic phantoms. When comparing the two reconstruction algorithms, filtered back projection (FBP) and ordered subset expectation maximisation (OSEM), trade-off plots of spatial resolution, contrast and noise were used. Development and optimisation of the CVT-method was performed using activity distributions mimicking various degrees of COPD. The CVT-method itself was used when the optimal combination of acquisition, reconstruction and analysis parameter values was determined. The radioactive tracer 99mTc-Technegas was used for the ventilation examination on human subjects.

OSEM resulted in higher spatial resolution in combination with lower noise level compared to FBP and was therefore chosen. The optimal parameter values found were a total number of counts in the projections of at least 3.6 x 106 and a low energy highresolution collimator. The number of OSEM updates and cut-off frequency of the noise reduction filter depended on if the periphery of the lung was excluded or not. The CVT-method showed to be capable of identifying early COPD in computersimulated images (p<0.001). The CVT-method was also capable of correctly identifying patients with severe COPD (p<0.05). A compensation technique was implemented, making the heterogeneity values from healthy lung volumes of different subjects comparable. This adaptation made it possible to identify subjects who had normal lung function tests but with indications of conditions associated with ventilation disturbances. The results indicate that the present method has the capacity to identify minor lung function abnormalities earlier in a disease process than conventional lung function tests.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 79 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1403
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-106667 (URN)10.3384/diss.diva-106667 (DOI)978-91-7519-359-5 (ISBN)
Public defence
2014-06-05, Eken, ingång 65 (HU) plan 9, Campus US, Linköpings universitet, Linköping, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2014-05-19 Created: 2014-05-19 Last updated: 2015-03-20Bibliographically approved

Open Access in DiVA

No full text

Authority records BETA

Norberg, PernillaOlsson, AnnaAlm Carlsson, GudrunSandborg, MichaelGustafsson, Agnetha

Search in DiVA

By author/editor
Norberg, PernillaOlsson, AnnaAlm Carlsson, GudrunSandborg, MichaelGustafsson, Agnetha
By organisation
Center for Medical Image Science and Visualization (CMIV)Division of Radiological SciencesFaculty of Health SciencesDepartment of Radiation Physics
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 86 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf