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Macrophage Infiltration in Tumor Stroma is Related to Tumor Cell Expression of CD163 in Colorectal Cancer
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
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2014 (English)In: Cancer Microenvironment, ISSN 1875-2292, E-ISSN 1875-2284, Vol. 7, no 1, 61-69 p.Article in journal (Refereed) Published
Abstract [en]

The scavenger receptor, CD163, is a macrophage-specific marker. Recent studies have shown that CD163 expression in breast and rectal cancer cells is associated with poor prognosis. This study was conducted to evaluate the relationship between CD163 expression as a macrophage trait in cancer cells, and macrophage infiltration and its clinical significance in colorectal cancer. Immunostaining of CD163 and macrophage infiltration were evaluated in paraffin-embedded specimens, earlier analyzed for CD31, D2-40 and S-phase fraction, from primary tumors and normal colorectal mucosa of 75 patients with colorectal carcinoma. The outcomes were analyzed in relation to clinical-pathological data. CD163 expression was positive in cancer cells in 20 % of colorectal cancer patients and was related to advanced tumor stages (P = 0.008) and unfavorable prognosis (p = 0.001). High macrophage infiltration was related to shorter survival and positive CD163 expression in tumor cells. The prognostic impact of macrophage infiltration was independent of tumor stage and CD163 expression in cancer cells (p = 0.034). The expression of macrophage phenotype in colorectal cancer cells is associated with macrophage density in tumor stroma and lower survival rates. Macrophage infiltration has an independent prognostic impact on mortality in colorectal cancer. In accordance with previous experimental studies, these findings provide new insights into the role of macrophages in colorectal cancer.

Place, publisher, year, edition, pages
Springer Netherlands, 2014. Vol. 7, no 1, 61-69 p.
Keyword [en]
CD163 expression, Macrophage infiltration, Colorectal cancer
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-106894DOI: 10.1007/s12307-014-0145-7PubMedID: 24771466OAI: oai:DiVA.org:liu-106894DiVA: diva2:719314
Available from: 2014-05-23 Created: 2014-05-23 Last updated: 2017-12-05Bibliographically approved

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Shabo, IvanOlsson, HansElkarim, RihabSun, Xiao-FengSvanvik, Joar

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Shabo, IvanOlsson, HansElkarim, RihabSun, Xiao-FengSvanvik, Joar
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Surgery in LinköpingDivision of Inflammation MedicineDepartment of Clinical Pathology and Clinical GeneticsDepartment of Oncology
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