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Preliminary Results: prospective clinical study to assess image-based iterative reconstruction for abdominal computed tomography acquired at 2 radiation dose levels
Massachusetts General Hospital, Boston, USA .
Massachusetts General Hospital, Boston, USA .
Massachusetts General Hospital, Boston, USA .
Massachusetts General Hospital, Boston, USA .
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2014 (English)In: Journal of computer assisted tomography, ISSN 0363-8715, E-ISSN 1532-3145, Vol. 38, no 1, 117-122 p.Article in journal (Refereed) Published
Abstract [en]


The objective of this study was to compare image quality for abdominal computed tomographic (CT) images acquired at 200 and 50 mA s and reconstructed with image-based iterative reconstruction.


In this institutional review board-approved prospective study, 22 patients (mean [SD] age, 64.3 [14.4] years; male-female ratio, 12:10) gave informed consent for acquisition of additional abdominal CT images on 64-slice multi-detector CT (MDCT) (Siemens Definition Flash). Standard-dose images were acquired at 200 quality reference mA s, whereas low-dose images were acquired at 50 mA s (all series: 120 kV; 5-mm section thickness; pitch, 0.9:1). The low-dose images were reconstructed with a nonlinear 3-dimensional iterative image reconstruction (3D-IIR) (SafeCT; MedicVision, Tirat Carmel, Israel) (4 settings, namely, A1, A2, A3, and A4) and were assessed by 3 abdominal radiologists for lesion detection, image noise, and visibility of small structures. CATPHAN 500 was scanned at the respective doses to obtain noise spectral density and modulation transfer function.


Subjective image noise was unacceptable at 50-mA s filtered back projection and improved to average in 50-mA s A1 and minimal or no noise in 50-mA s A4. However, the visibility of small structures was similar to standard-dose filtered back projection images on 50-mA s A2. Objective image noise was reduced to 66% for the 50-mA s 3D-IIR images (9.08 [2.3]/26.75 [6.8]). The modulation transfer function curve demonstrated resolution improvement in the low-dose images with the 3D-IIR technique, whereas the noise spectral density curve confirmed noise suppression in the 50-mA s 3D-IIR images.


Three-dimensional iterative image reconstruction helps to lower image noise without affecting the visibility of small structures at "moderate" settings. Diagnostically acceptable abdominal CT examinations can be acquired at 75% lower-radiation dose with the help of the image-based iterative reconstruction technique.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2014. Vol. 38, no 1, 117-122 p.
Keyword [en]
radiation dose reduction; multidetector CT; iterative reconstruction technique
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-106989DOI: 10.1097/RCT.0b013e3182a17629ISI: 000335389700020PubMedID: 24424560OAI: diva2:721057
Available from: 2014-06-03 Created: 2014-06-02 Last updated: 2014-06-11Bibliographically approved

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Persson, Anders
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Division of Radiological SciencesFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Radiology in Linköping
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Journal of computer assisted tomography
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