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Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children
Erasmus MC, Netherlands Erasmus MC, Netherlands Erasmus MC, Netherlands .
Erasmus MC, Netherlands Erasmus University, Netherlands Erasmus University, Netherlands .
Erasmus Medical Center, Rotterdam, The Netherlands.
Erasmus MC, Netherlands INSERM, France University of Paris 06, France .
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2014 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 133, no 5, 1317-1329 p.Article in journal (Refereed) Published
Abstract [en]

Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age less than 37 weeks) and low birth weight (less than 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P less than. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 133, no 5, 1317-1329 p.
Keyword [en]
Gestational age; low birth weight; infant growth; wheezing; asthma; children; cohort studies; epidemiology
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-107117DOI: 10.1016/j.jaci.2013.12.1082ISI: 000335450700012OAI: oai:DiVA.org:liu-107117DiVA: diva2:722037
Available from: 2014-06-05 Created: 2014-06-05 Last updated: 2017-12-05

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Duchén, KarelLudvigsson, Johnny

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Duchén, KarelLudvigsson, Johnny
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Gynaecology and Obstetrics in LinköpingDepartment of Paediatrics in Linköping
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Journal of Allergy and Clinical Immunology
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