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Systemic Lupus Prevalence in Sweden in 2010: What do national registers say?
Karolinska Institutet, Stockholm; Stanford School of Medicine, CA, USA.
Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology. Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine.
Uppsala University, Sweden.
Lund University, Sweden.
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2014 (English)In: Arthritis care & research, ISSN 2151-4658, Vol. 66, no 11, 1710-1717 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3-207 per 100,000 depending on region and population, SLE definition, case sources and other methodological considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010 using population-based registers.

Methods: Linking multiple national registers we identified all possible inpatient and outpatient visits with SLE-specific discharge diagnoses and relevant prescription dispensations among living individuals registered in Sweden on January 1, 2010. SLE was defined from a lenient classification (requiring only a single visit) to stricter definitions, which required multiple visits with a history of relevant specialist care and a dispensation for common SLE medications. Prevalence was calculated overall, and by sex, age (0-14, 15-49, 50+yrs, as well as in 5-year age groups), and county of residence.

Result: Overall prevalence ranged from 46 per 100,000 for the strictest definition to 85 per 100,000 for the least strict definition. As expected, SLE was more common among females (ranged from 79 to 144/100,000) than males (12-25/100,000) and varied by age. The up to four-fold variation by county was unexpected. Prevalence generally increased with age (2, 52, and 95 per 100,000 by increasing age group, 0-14/15-49/50+, using a moderately strict definition) and also varied by county.

Conclusion: Variations of prevalence by age and sex were consistent with previous studies and overall ranged from 46 to 85 per 100,000. We observed a surprising geographical variation in the prevalence of SLE in Sweden on January 1, 2010 according to multiple definitions.

Place, publisher, year, edition, pages
John Wiley & Sons, 2014. Vol. 66, no 11, 1710-1717 p.
Keyword [en]
Prevalence; Systemic Lupus Erythematosus; Epidemiology; Health services research
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-107237DOI: 10.1002/acr.22355ISI: 000344334200015PubMedID: 24757083OAI: diva2:723057
Available from: 2014-06-10 Created: 2014-06-10 Last updated: 2014-12-08

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Sjöwall, Christopher
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Faculty of Health SciencesDepartment of RheumatologyDivision of Inflammation Medicine
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