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Serum Folic Acid and RFC A80G Polymorphism in Alzheimers Disease and Vascular Dementia
All India Institute Medical Science, India .
All India Institute Medical Science, India .
All India Institute Medical Science, India .
All India Institute Medical Science, India .
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2014 (English)In: American Journal of Alzheimer’s Disease and Other Dementia, ISSN 1533-3175, E-ISSN 1938-2731, Vol. 29, no 1, 38-44 p.Article in journal (Refereed) Published
Abstract [en]

Low level of vitamin B12 and folic acid has been reported to play an important role in the pathogenesis of Alzheimer's disease (AD) and vascular dementia (VaD). Serum folic acid and vitamin B12 were assayed in 80 AD and 50 VaD cases and in 120 healthy controls. The reduced folate carrier (RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction-restriction fragment length polymorphism. It was observed that the patients having folic acid <8.45 ng/mL had 2.4 (95% confidence interval [CI]: 1.4-4.5) times higher odds of having AD and 2.1 (95% CI: 1.1-4.2) times higher odds of having VaD than patients having folic acid ≥8.45 ng/mL. Serum vitamin B12 level did not show any such statistically significant effect in altering the odds. No direct association was found between variant (G) allele or genotype of rs1051266 with AD and VaD cases. On serum folate level no association was observed with gene polymorphism.

Place, publisher, year, edition, pages
SAGE Publications (UK and US) , 2014. Vol. 29, no 1, 38-44 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-107465DOI: 10.1177/1533317513505131ISI: 000331463000006Scopus ID: 2-s2.0-84896735112OAI: oai:DiVA.org:liu-107465DiVA: diva2:724290
Available from: 2014-06-12 Created: 2014-06-12 Last updated: 2017-12-05

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Sharma, Sumit

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