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Sound‐Evoked Length Changes of the Outer Hair Cell Stereocilia Bundle are Modulated by Endocochlear Currents
Linköping University, Department of Clinical and Experimental Medicine.ORCID iD: 0000-0001-9615-3885
2011 (English)Conference proceedings (editor) (Refereed)
Abstract [en]

The apical surface of vertebrate inner ear sensory cells is characterized by a bundle of giant microvilli commonly known as stereocilia. Stereocilia bend about a neck‐like thinning near their base and more than three decades of research has established that the direction and magnitude of sideways bundle deflection is the basis of the mechanoelectrical signalling that initiates sound perception. Aside from its ability to bend at the neck, the stereocilium is usually considered as a stiff inelastic rod. Here we show that the length of OHC stereocilia changes during sound transduction, demonstrating their axial compliance, and that the magnitude of the length change is modulated by currents that mimic in vivo endocochlear currents. A reciprocal relation between length change and bundle deflection is evident: the smaller the length changes, the larger the bundle deflection.

Place, publisher, year, edition, pages
American Institute of Physics (AIP), 2011.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-107585DOI: 10.1063/1.3658056OAI: diva2:725713
AIP Conf. Williamstown, 2011. Massachusetts (USA)
Available from: 2014-06-17 Created: 2014-06-17 Last updated: 2015-02-09

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Hakizimana, Pierre
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Department of Clinical and Experimental Medicine
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