Decreasing Outer Hair Cell Membrane Cholesterol Increases Cochlear Electromechanics
2011 (English)Conference proceedings (editor) (Refereed)
Place, publisher, year, edition, pages
American Institute of Physics (AIP), 2011.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-107589DOI: 10.1063/1.3658076OAI: oai:DiVA.org:liu-107589DiVA: diva2:725717
AIP Conf. 2011. Williamstown, Massachusetts (USA)
The effect of decreasing membrane cholesterol on the mechanical response of the cochlea to acoustic and/or electrical stimulation was monitored using laser interferometry. In contrast to pharmacological interventions that typically decrease cochlear electromechanics, reducing membrane cholesterol increased the response. The electromechanical response in untreated preparations was asymmetric with greater displacements in response to positive currents and cholesterol depletion increased the asymmetry. The results confirm that outer hair cell electromotility is enhanced by low membrane cholesterol. The asymmetry of the response indicates the outer hair cell resting membrane potential is hyperpolarized relative to the voltage of maximum gain for the outer hair cell voltage‐displacement function. The magnitude of the response increase suggests a non‐uniform distribution of cholesterol along the lateral wall of normal adult outer hair cells.2014-06-172014-06-172015-02-09