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Decreasing Outer Hair Cell Membrane Cholesterol Increases Cochlear Electromechanics
Otolaryngology—H&N Surgery, Baylor College of Medicine, USA.
Center for Hearing and Communication Research, Karolinska Institutet.
Center for Hearing and Communication Research, Karolinska Institutet.ORCID iD: 0000-0001-9615-3885
Center for Hearing and Communication Research, Karolinska Institutet.
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2011 (English)In: WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS: PROCEEDINGS OF THE 11TH INTERNATIONAL MECHANICS OF HEARING WORKSHOP / [ed] Shera, CA; Olson, ES, American Institute of Physics (AIP), 2011, Vol. 1403Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
American Institute of Physics (AIP), 2011. Vol. 1403
Series
AIP Conference Proceedings, ISSN 0094-243X ; 1403
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-107589DOI: 10.1063/1.3658076ISI: 000301945200025ISBN: 978-0-7354-0975-0 (print)OAI: oai:DiVA.org:liu-107589DiVA: diva2:725717
Conference
AIP Conf. 2011. Williamstown, Massachusetts (USA)
Note

The effect of decreasing membrane cholesterol on the mechanical response of the cochlea to acoustic and/or electrical stimulation was monitored using laser interferometry. In contrast to pharmacological interventions that typically decrease cochlear electromechanics, reducing membrane cholesterol increased the response. The electromechanical response in untreated preparations was asymmetric with greater displacements in response to positive currents and cholesterol depletion increased the asymmetry. The results confirm that outer hair cell electromotility is enhanced by low membrane cholesterol. The asymmetry of the response indicates the outer hair cell resting membrane potential is hyperpolarized relative to the voltage of maximum gain for the outer hair cell voltage‐displacement function. The magnitude of the response increase suggests a non‐uniform distribution of cholesterol along the lateral wall of normal adult outer hair cells.

Available from: 2014-06-17 Created: 2014-06-17 Last updated: 2017-01-18

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Hakizimana, Pierre

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CiteExportLink to record
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