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The contribution of hypoxia to the association between sleep apnoea, insomnia, and cardiovascular mortality in community-dwelling elderly with and without cardiovascular disease
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.ORCID iD: 0000-0001-7431-2873
Swedish Defence Research Agency, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Health Sciences.
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2015 (English)In: European Journal of Cardiovascular Nursing, ISSN 1474-5151, E-ISSN 1873-1953, Vol. 14, no 3, 222-231 p.Article in journal (Refereed) Published
Abstract [en]

Aims:

This study explores if nightly hypoxia (i.e. percentage of sleep time with oxygen saturation lower than 90% (SaO2<90%)) contributed to the association between sleep-disordered breathing (SDB) and insomnia in community-dwelling elderly with and without cardiovascular disease (CVD). A second aim was to explore a potential cut-off score for hypoxia to predict insomnia and the association of the cut-off with clinical characteristics and cardiovascular mortality.

Method:

A total of 331 community-dwelling elderly aged 71–87 years underwent one-night polygraphic recordings. The presence of insomnia was recorded by a self-report questionnaire. The presence of CVD was objectively established and mortality data were collected after three and six years.

Results:

In both patients with CVD (n=119) or without CVD (n=212) SDB was associated with hypoxia (p<0.005). Only in the patients with CVD was hypoxia associated with insomnia (p<0.001) which mediated an indirect effect (p<0.05) between SDB and insomnia. Hypoxia of more than 1.5% of sleep time with SaO2<90% was found to be a critical level for causing insomnia. According to this criterion 32% (n=39) and 26% (n=55) of those with and without CVD had hypoxia, respectively. These groups did not differ with respect to age, gender, body mass index, diabetes, hypertension, respiratory disease or levels of SDB. However, in the CVD group, hypoxia was associated with cardiovascular mortality at the three-year follow-up (p=0.008) and higher levels of insomnia (p=0.002).

Conclusion:

In the elderly with CVD, SDB mediated by hypoxia can be associated with more insomnia and a worse prognosis.

Place, publisher, year, edition, pages
Sage Publications, 2015. Vol. 14, no 3, 222-231 p.
Keyword [en]
Elderly, cardiovascular disease, sleep-disordered breathing, hypoxia, insomnia
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-107677DOI: 10.1177/1474515114524072ISI: 000354116400006PubMedID: 24509843OAI: oai:DiVA.org:liu-107677DiVA: diva2:726525
Available from: 2014-06-18 Created: 2014-06-18 Last updated: 2017-12-05

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Johansson, PeterAlehagen, UrbanJaarsma, TinyBroström, Anders

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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Cardiology in LinköpingDivision of Health, Activity and Care
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European Journal of Cardiovascular Nursing
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