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Regional differences in screening for retinopathy of prematurity in infants born before 27 weeks of gestation in Sweden - the EXPRESS study
Uppsala University, Sweden University of Trondheim Hospital, Norway .
Lund University, Sweden .
University of Gothenburg, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
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2014 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 92, no 4, 311-315 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: The primary aim was to analyse regional incidences of retinopathy of prematurity (ROP) and frequencies of treatment and their relation to perinatal risk factors during a 3-year period. A secondary aim was to study adherence to the study screening protocol in the different regions. Methods: A population-based study of neonatal morbidity in extremely preterm infants in Sweden (EXPRESS) was performed during 2004-2007. Screening for ROP was to start at postnatal age 5weeks and to continue weekly until the retina was completely vascularized or until regression of ROP. Logistic regression analyses were used for evaluation of differences in incidence of Any ROP, ROP 3 or more and ROP Type 1 between the seven regions of the country. Results: The regional incidence of ROP varied between 54% and 92% for Any ROP, between 25% and 43% for ROP stage 3 or more and between 8% and 23% of infants with ROP Type 1, all of whom were treated. There was no significant difference between the regions regarding ROP Type 1, even when adjusting for known risk factors for ROP. Conclusion: The heterogeneity between the regions regarding the incidence of ROP was reduced with increasing severity of ROP, and there was no heterogeneity regarding frequency of treatment for ROP, which is the most important issue for the children. We cannot exclude observer bias regarding mild ROP and ROP stage 3 in this study.

Place, publisher, year, edition, pages
Wiley , 2014. Vol. 92, no 4, 311-315 p.
Keyword [en]
retinopathy of prematurity; population-based; extremely preterm; screening, observer bias
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-107823DOI: 10.1111/aos.12165ISI: 000336443600012OAI: diva2:727943
Available from: 2014-06-23 Created: 2014-06-23 Last updated: 2014-06-23

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Jakobsson, Peter
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Division of NeuroscienceFaculty of Health SciencesDepartment of Ophthalmology in Linköping
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