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Vitamin D deficiency in elderly people in Swedish nursing homes is associated with increased mortality
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in West Östergötland, Primary Health Care in Motala.
Lund University, Malmö, Sweden.
Futurum, Jönköping, Sweden.
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2014 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 170, no 5, 667-675 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE:

Institutionalised elderly people at northern latitudes may be at elevated risk for vitamin D deficiency. In addition to osteoporosis-related disorders, vitamin D deficiency may influence several medical conditions conferring an increased mortality risk. The aim of this study was to explore the prevalence of vitamin D deficiency and its association with mortality.

DESIGN:

The Study of Health and Drugs in the Elderly (SHADES) is a prospective cohort study among elderly people (>65 years) in 11 nursing homes in Sweden.

METHODS:

We analysed the levels of 25-hydroxyvitamin D₃ (25(OH)D₃) at baseline. Vital status of the subjects was ascertained and hazard ratios (HRs) for mortality according to 25(OH)D₃ quartiles were calculated.

RESULTS:

We examined 333 study participants with a mean follow-up of 3 years. A total of 147 (44%) patients died within this period. Compared with the subjects in Q4 (25(OH)D₃ >48  nmol/l), HR (with 95% CI) for mortality was 2.02 (1.31-3.12) in Q1 (25(OH)D₃ <29  nmol/l) (P<0.05); 2.03 (1.32-3.14) in Q2 (25(OH)D₃ 30-37  nmol/l) (P<0.05) and 1.6 (1.03-2.48) in Q3 (25(OH)D₃ 38-47  nmol/l) (P<0.05). The mean 25(OH)D₃ concentration was 40.2  nmol/l (S.D. 16.0) and 80% had 25(OH)D₃ below 50  nmol/l. The vitamin D levels decreased from baseline to the second and third measurements.

CONCLUSIONS:

Vitamin D deficiency was highly prevalent and associated with increased mortality among the elderly in Swedish nursing homes. Strategies are needed to prevent, and maybe treat, vitamin D deficiency in the elderly in nursing homes and the benefit of vitamin D supplementation should be evaluated in randomised clinical trials.

Place, publisher, year, edition, pages
Bioscientifica, 2014. Vol. 170, no 5, 667-675 p.
National Category
Gerontology, specializing in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-108174DOI: 10.1530/EJE-13-0855ISI: 000336728100008PubMedID: 24520134OAI: oai:DiVA.org:liu-108174DiVA: diva2:729560
Available from: 2014-06-26 Created: 2014-06-26 Last updated: 2017-12-05Bibliographically approved

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Samefors, MariaÖstgren, Carl Johan

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Division of Community MedicineFaculty of Health SciencesPrimary Health Care in Motala
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