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The placenta in toxicology. Part I: Animal models in toxicology
Covance Laboratories, Münster, Germany.
Department of Anatomy, University of Veterinary Medicine, Hannover, Germany.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
Placenta-Labor, Department of Obstetrics, University Hospital, Jena, Germany.
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2014 (English)In: Toxicologic pathology (Print), ISSN 0192-6233, E-ISSN 1533-1601, Vol. 42, no 2, 314-326 p.Article in journal (Refereed) Published
Abstract [en]

The immune system represents a key defense mechanism against potential pathogens and adverse non-self materials. During pregnancy, the placenta is the point of contact between the maternal organism and non-self proteins of the fetal allograft and hence undoubtedly fulfils immune functions. In the placenta bacteria, foreign (non-self) proteins and proteins that might be introduced in toxicological studies or by medication are barred from reaching the progeny, and the maternal immune system is primed for acceptance of non-maternal fetal protein. Both immunologic protection of the fetus and acceptance of the fetus by the mother require effective mechanisms to prevent an immunologic fetomaternal conflict and to keep both organisms in balance. This is why the placenta requires toxicological consideration in view of its immune organ function. The following articles deal with placenta immune-, control-, and tolerance mechanisms in view of both fetal and maternal aspects. Furthermore, models for experimental access to placental immune function are addressed and the pathological evaluation is elucidated. "The Placenta as an Immune Organ and Its Relevance in Toxicological Studies" was subject of a continuing education course at the 2012 Society of Toxicologic Pathology meeting held in Boston, MA.

Place, publisher, year, edition, pages
Sage Publications, 2014. Vol. 42, no 2, 314-326 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-108388DOI: 10.1177/0192623313482208ISI: 000337625300003PubMedID: 23548606OAI: diva2:730166
Available from: 2014-06-27 Created: 2014-06-27 Last updated: 2015-03-25Bibliographically approved

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Svensson-Arvelund, JuditErnerudh, Jan
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Division of Inflammation MedicineFaculty of Health SciencesDepartment of Clinical Immunology and Transfusion Medicine
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Toxicologic pathology (Print)
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