liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Surface nanoengineered contact lens as a wearable point-of-care diagnostics platform
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-1222-6720
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-1815-9699
Linköping University, Faculty of Health Sciences.
Show others and affiliations
2014 (English)In: 24th Anniversary World Congress on Biosensors – Biosensors 2014, Elsevier, 2014Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Detection of biomarkers is essential for disease prevention, diagnosis, and prognosis of early stage treatment. Ocular fluid is an extracellular fluid excreted from the tear gland. Several important markers from ocular fluid have been identified having significant clinical diagnostic value for various diseases. The contact lens is disposable, relatively cheap and serves as a platform to obtain direct intimate contact with ocular fluid and is therefore an attractive and a promising platform for point-of-care diagnostic tests. Here, we present an innovative concept of a wearable contact lens biosensor with nanoengineered biorecognition architecture based on a Layer-by-Layer (LbL) technique on the contact lens surface. This technique enables us to deposit multiple layers of biomolecules to create biorecognition layer under a mild aqueous physiological temperature and pH conditions. The fabrication of the biorecognition layer is simply through physical adsorption and has no restrictions with respect to the substrate size and topology (i.e. contact lens). The thickness of the resulting biorecognition layer is only hundreds of nanometers, and hence has minimal influence on the overall thickness of the contact lens, thus preserving the optical properties of the contact lens for vision correction. We have demonstrated that eye inflammation biomarkers such as interleukin (IL) can be captured in vitro with the contact lens, thus facilitating colorimetric affinity bioassays to measure the amount of interleukin. An in vitro ocular model composed of hydrogel-based artificial cornea and microfluidics was developed to study the performance of the contact lens biosensing platform. The contact  platform was able to detect IL-1α down to the physiological concentration, which is in the range of pg mL-1. There is a recent trend away from handheld devices towards wearable systems, illustrated by popular technology such as “Google glasses” and the “i-Watch”. We believe that the concept of wearable diagnostics holds significant promise as the next generation point-of-care diagnostic platform and that this contact lens-based approach is a convenient platform for a number of important applications.

Place, publisher, year, edition, pages
Elsevier, 2014.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-108428OAI: oai:DiVA.org:liu-108428DiVA: diva2:730292
Conference
24th Anniversary World Congress on Biosensors – Biosensors 2014, 27-30 May 2014, Melbourne, Australia
Available from: 2014-06-27 Created: 2014-06-27 Last updated: 2014-08-26

Open Access in DiVA

No full text

Other links

http://www.biosensors-congress.elsevier.com/

Authority records BETA

Griffith, MayTurner, Anthony

Search in DiVA

By author/editor
Griffith, MayTurner, Anthony
By organisation
Biosensors and BioelectronicsThe Institute of TechnologyDivision of Cell BiologyFaculty of Health Sciences
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 492 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf