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Switchable bioelectronics on a graphene interface
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-1815-9699
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
2014 (English)In: 24th Anniversary World Congress on Biosensors – Biosensors 2014, Elsevier, 2014Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

Smart and flexible bioelectronics on graphene have emerged as a new frontier in the field of biosensors and bioelectronics [1]. Graphene has begun to be seen as an ideal signal transducer and a promising alternative for the production of low-cost bioelectronic devices. However, biological systems used in these devices suffer from a lack of control and regulation. There is an obvious need to develop “switchable” and “smart” interfaces for both fundamental and applied studies [2]. Here, we report for the first time the fabrication of an on/off-switchable graphene interface, which is used to regulate biomolecular reactions.

    The present study aims to address the design and development of a novel auto-switchable graphene bio-interface that is capable of positively responding, by creating unique “zipper” nanoarchitectures. The zipper consists of a two-dimensional graphene donor and a polymeric receptor, which are rationally assembled together based in a stoichiometric donor-receptor interaction. Preferably, at a relatively low temperature (20 oC) the active donor-receptor interaction (hydrogen bonding) creates a coalescence of the graphene interface, thereby causing considerable shrinkage in the donor-to-receptor interface. Thus access of an associated enzyme to its substrate is largely restricted, resulting in a decrease in the diffusion of reactants and the consequent activity of the system. In contrast, at a comparatively high temperature (40 oC) the donor-receptor interaction was subverted. As a result, the biosubstrate could freely access the enzyme facilitating bioelectrocatalysis. More importantly, this provides the first example of responsive bioelectronics being achieved on a two-dimensional graphene interface by controlling the external temperature as an on/off-switchable model.

     Using electrochemical techniques, we demonstrated that interfacial bio-electrochemical properties can be tuned by modest changes in temperature. Such an ability to independently regulate the behaviour of the interface has important implications for the design of novel bioreactors, biofuel cells and biosensors with inbuilt self-control features.

 

Place, publisher, year, edition, pages
Elsevier, 2014.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-108431OAI: oai:DiVA.org:liu-108431DiVA: diva2:730299
Conference
24th Anniversary World Congress on Biosensors – Biosensors 2014, 27-30 May 2014, Melbourne, Australia
Funder
Swedish Research Council
Available from: 2014-06-27 Created: 2014-06-27 Last updated: 2014-08-26

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Parlak, OnurTurner, AnthonyTiwari, Ashutosh

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