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Chromogranin A as a biomarker in cardiovascular disease
Rigshospitalet, University of Copenhagen, Denmark .
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping.
Aarhus University Hospital, Denmark.
Rigshospitalet, University of Copenhagen, Denmark .
2014 (English)In: Biomarkers in medicine, ISSN 1752-0363, EISSN 1752-0371, Vol. 8, no 1, 133-140 p.Article in journal (Refereed) Published
Abstract [en]

Chromogranin A is known as an important marker of neuroendocrine tumors. In cardiovascular medicine, however, chromogranin A measurement has only recently gained interest, since increased concentrations in the circulation are associated with risk of clinical worsening and death in patients with acute coronary syndromes or chronic heart failure. In this article, we summarize the current clinical data on chromogranin A as a biomarker in cardiovascular disease from high-risk conditions; for example, obesity, hypertension and diabetes, to overt heart failure. Biological activity of the various chromogranin A fragments, including the intact precursor itself, will not be covered in the present review. Instead, we highlight the complexity of chromogranin A as a plasma marker, where the protein is extensively and variably processed to a plethora of peptide fragments. Current immunological methods for clinical measurement differ dramatically with respect to both epitope choice and clinical validation.

Place, publisher, year, edition, pages
Future Medicine , 2014. Vol. 8, no 1, 133-140 p.
Keyword [en]
ANP; BNP; cardiovascular; chromogranin A; heart disease; heart failure; natriuretic peptide
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-108607DOI: 10.2217/bmm.13.102ISI: 000337220700023PubMedID: 24325234OAI: diva2:731181
Available from: 2014-07-01 Created: 2014-07-01 Last updated: 2014-09-01Bibliographically approved

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Alehagen, Urban
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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Cardiology in Linköping
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