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Influence of conductive polymer doping on the viability of cardiac progenitor cells
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0001-6024-4144
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-2071-7768
2014 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 2, no 24, 3860-3867 p.Article in journal (Refereed) Published
Abstract [en]

Cardiac tissue engineering via the use of stem cells is the future for repairing impaired heart function that results from a myocardial infarction. Developing an optimised platform to support the stem cells is vital to realising this, and through utilising new smart materials such as conductive polymers we can provide a multi-pronged approach to supporting and stimulating the stem cells via engineered surface properties, electrical, and electromechanical stimulation. Here we present a fundamental study on the viability of cardiac progenitor cells on conductive polymer surfaces, focusing on the impact of surface properties such as roughness, surface energy, and surface chemistry with variation of the polymer dopant molecules. The conductive polymer materials were shown to provide a viable support for both endothelial and cardiac progenitor cells, while the surface energy and roughness were observed to influence viability for both progenitor cell types. Characterising the interaction between the cardiac progenitor cells and the conductive polymer surface is a critical step towards optimising these materials for cardiac tissue regeneration, and this study will advance the limited knowledge on biomaterial surface interactions with cardiac cells.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2014. Vol. 2, no 24, 3860-3867 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-108817DOI: 10.1039/c4tb00142gISI: 000336853400015OAI: oai:DiVA.org:liu-108817DiVA: diva2:732881
Available from: 2014-07-07 Created: 2014-07-06 Last updated: 2017-12-05Bibliographically approved

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Gelmi, AmyKozak Ljunggren, MonikaRafat, MehrdadJager, Edwin

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Gelmi, AmyKozak Ljunggren, MonikaRafat, MehrdadJager, Edwin
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Biosensors and BioelectronicsThe Institute of TechnologyDivision of Cell BiologyFaculty of Health SciencesDepartment of Biomedical Engineering
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Journal of materials chemistry. B
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