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Dark States in Ionic Oligothiophene Bioprobes-Evidence from Fluorescence Correlation Spectroscopy and Dynamic Light Scattering
Royal Institute Technology, Sweden .
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
Royal Institute Technology, Sweden .
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
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2014 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 118, no 22, 5924-5933 p.Article in journal (Refereed) Published
Abstract [en]

Luminescent conjugated polyelectrolytes (LCPs) can upon interaction with biological macromolecules change their luminescent properties, and thereby serve as conformation- and interaction-sensitive biomolecular probes. However, to exploit this in a more quantitative manner, there is a need to better understand the photophysical processes involved. We report studies of the conjugated pentameric oligothiophene, derivative p-FTAA, which changes optical properties with different p-FTAA concentrations in aqueous buffers, and in a pH and oxygen saturation dependent manner. Using dynamic light scattering, luminescence spectroscopy and fluorescence correlation spectroscopy, we find evidence for a monomer dimer equilibrium, for the formation of large clusters of p-FTAA in aqueous environment, and can couple aggregation to changed emission properties of oligothiophenes. In addition, we observe the presence of at least two dark transient states, one presumably being a triplet state. Oxygen was found to statically quench the p-FTAA fluorescence but also to promote molecular fluorescence by quenching dark transient states of the p-FTAA molecules. Taken together, this study provides knowledge of fluorescence and photophysical features essential for applying p-FTAA and other oligothiophene derivatives for diagnostic purposes, including detection and staining of amyloid aggregates.

Place, publisher, year, edition, pages
American Chemical Society , 2014. Vol. 118, no 22, 5924-5933 p.
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Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-108795DOI: 10.1021/jp501324eISI: 000337011400013OAI: oai:DiVA.org:liu-108795DiVA: diva2:732918
Available from: 2014-07-07 Created: 2014-07-06 Last updated: 2017-12-05

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Wigenius, JensInganäs, Olle

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