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Influence of Life Style Factors on Barretts Oesophagus
Karolinska University Hospital, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Norrköping.
2014 (English)In: Gastroenterology Research and Practice, ISSN 1687-6121, E-ISSN 1687-630X, Vol. 2014, no 408470Article in journal (Refereed) Published
Abstract [en]

Background. Since the incidence of adenocarcinoma of the oesophagus is rising, the prognosis is poor, and surveillance programs are expensive and mostly cost ineffective, there is a need to increase the knowledge of risk factors in Barretts oesophagus and oesophageal cancer in order to be able to give attention to medical prevention and/or surveillance programs. Aim. To study if there is a correlation between the development of Barretts oesophagus and GOR (gastro oesophageal reflux), family history of GOR, and life style factors, such as alcohol, smoking habits, and mental stress. Methods. Fifty-five consecutively selected patients with Barretts oesophagus (BO) examined at Linkoping University Hospitals Oesophageal Laboratory were matched by sex, age, and duration of reflux symptoms with 55 GOR patients without Barretts oesophagus at the Oesophageal Laboratory. The medical charts in respective groups were examined for comparison of life style factors, mental stress, medication, duration of gastroesophageal acid reflux at 24 hr-pH-metry, and incidence of antireflux surgery and of adenocarcinoma of the oesophagus (ACO). Also, potential gender differences and diagnosis of ACO were studied. Results. Mean percentage reflux time on 24 hr-pH-metry was higher for the Barretts oesophagus group, 18% for women and 17% for men compared to 4% for women and 4% for men in the control group (P less than 0.05). Family history of GOR was more frequent in Barretts oesophagus patients (62%) than in the control group (35%) (P less than 0.05). Male patients with Barretts oesophagus had medical therapy for their GOR symptoms to a higher extent (38%) than male controls (65%) (P less than 0.05). No difference was found in the number of tobacco users or former tobacco users between Barretts oesophagus patients and controls. Barretts oesophagus patients had the same level of alcohol consumption and the same average BMI as the control subjects. Female patients with Barretts oesophagus rated themselves as more mentally stressed (67%) than the female controls (38%) (P less than 0.05). In the five-year medical chart follow-up, five of 55 patients developed adenocarcinoma among the Barretts oesophagus patients, none in the control group. Conclusions. Long reflux time and family clustering of GOR seem to influence the development of Barretts oesophagus. Smoking habits, alcohol consumption and BMI do not seem to have any impact on the development of Barretts oesophagus.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation , 2014. Vol. 2014, no 408470
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-108946DOI: 10.1155/2014/408470ISI: 000337369300001OAI: diva2:734180
Available from: 2014-07-15 Created: 2014-07-13 Last updated: 2014-08-13

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Franzen, Thomas
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Surgery in Norrköping
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