Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast
2014 (English)In: Lasers in Medical Science, ISSN 0268-8921, E-ISSN 1435-604X, Vol. 29, no 3, 1189-1194 p.Article in journal (Refereed) Published
Cytotoxic effects of zinc oxide (ZnO) nanomaterials, individual and conjugated with a photosensitizer (protoporphyrin IX), were studied in the presence and absence of ultraviolet light exposure (240 nm of light wavelength for a very short time exposure) in cell cultures of human normal and cancerous skin models. Zinc Oxide nanowires (ZnO NWs) were grown on the capillary tip and conjugated with protoporphyrin IX (PpIX). This coated tip was used as tool/pointer for intracellular drug delivery protocol in suggested normal as well as carcinogenic cellular models. After true delivery of optimal drug, the labelled biological model was irradiated with UV-A, which led to a loss of mitochondrial membrane potential, as tested by neutral red assay (NRA).
Place, publisher, year, edition, pages
Springer London, 2014. Vol. 29, no 3, 1189-1194 p.
Protoporphyrin 1X (PpIX); ZnO nanowires (ZnO NWs)
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-108938DOI: 10.1007/s10103-013-1501-4ISI: 000337248300043OAI: oai:DiVA.org:liu-108938DiVA: diva2:734188