Functional goal achievement in post-stroke spasticity patients: The BOTOX® Economic Spasticity Trial (BEST)
2014 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, Vol. 46, no 6, 504-513 p.Article in journal (Refereed) Published
Evaluate changes in active and passive function with onabotulinumtoxinA + standard of care within goal-oriented rehabilitation programmes in adults with focal post-stroke spasticity.
Prospective, 24-week double-blind study with an open-label extension. Subjects were randomized to onabotulinumtoxinA + standard of care or placebo + standard of care, at baseline and at 12 weeks, if judged appropriate, with follow-up to 52 weeks. The primary endpoint was the number of patients achieving their principal active functional goal at 24 weeks (or 10 weeks after an optional second injection). Secondary endpoints included achievement of a different active or a passive goal at this timepoint.
The intent-to-treat population comprised 273 patients. The proportion of patients achieving their principal active functional goal and secondary active functional goal with onabotulinumtoxinA + standard of care was not statistically different from placebo + standard of care. Significantly more patients achieved their secondary passive goal with onabotulinumtoxinA + standard of care (60.0%) vs. placebo + standard of care (38.6%) (odds ratio, 2.46; 95% confidence interval, 1.18-5.14) as well as higher Goal Attainment Scaling levels for upper limb and ankle flexor subgroups.
Addition of onabotulinumtoxinA to standard of care as part of goal-oriented rehabilitation in post-stroke spasticity patients significantly increased passive goal achievement and was associated with higher levels of active function.
Place, publisher, year, edition, pages
Foundation for Rehabilitation Information , 2014. Vol. 46, no 6, 504-513 p.
botulinum neurotoxin A; functional change; goal attainment scaling; onabotulinumtoxinA; post-stroke spasticity; rehabilitation
IdentifiersURN: urn:nbn:se:liu:diva-109282DOI: 10.2340/16501977-1817ISI: 000338393300003PubMedID: 24715249OAI: oai:DiVA.org:liu-109282DiVA: diva2:737135