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Urea rebound assessment based on UV-absorbance in spent dialysate
Tallinn University of Technology, Estonia .
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology. Tallinn University of Technology, Estonia .
Tallinn University of Technology, Estonia .
2014 (English)In: ASAIO journal (1992), ISSN 1058-2916, E-ISSN 1538-943X, Vol. 60, no 4, 459-465 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to examine the possibility of post-dialysis urea rebound assessment using UV-absorbance measurements in spent dialysate. Twenty-six patients on chronic three-times-a-week hemodialysis (HD) were studied in two separate studies. Double-beam spectrophotometer was used for the determination of UV absorbance in the collected spent dialysate samples. Also, on-line UV absorbance was monitored. The equilibrium concentration (C-eq) of urea at the end of the rebound phase was calculated based on urea concentration in blood and dialysate and UV absorbance in spent dialysate. Based on C-eq, urea rebound was expressed relative to urea concentration at the end of HD (R-1) and relative to the decrease in urea concentration during HD (R-2). Estimates based on UV-absorbance values in spent dialysate (R-1_a, R-2_a) slightly over assess postdialysis rebound compared with results based on the blood sample drawn 30 min after HD (R-1_30post, R-2_30post), but R-1_a and R-2_a presented greater consistency and accuracy compared with the estimates based on the intradialytic blood sample (R-1_b, R-2_b). In summary, the results show that it is possible to assess postdialysis urea rebound in blood based on UV-absorbance measurements in spent dialysate.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2014. Vol. 60, no 4, 459-465 p.
Keyword [en]
hemodialysis monitoring; rebound; urea; UV absorption
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-109227DOI: 10.1097/MAT.0000000000000091ISI: 000338777600017PubMedID: 24814831OAI: diva2:737198
Available from: 2014-08-12 Created: 2014-08-11 Last updated: 2015-03-31Bibliographically approved

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Uhlin, Fredrik
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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Nephrology
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