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Functional magnetic resonance imaging in narcolepsy and the Kleine–Levin syndrome
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-2167-2450
Sahlgrenska Academy, University of Gothenburg, Sweden.
Sahlgrenska Academy, University of Gothenburg. Sweden; Halmstad County Hospital, Sweden.
Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). (Linnaeus Centre HEAD)
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2014 (English)In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 5, no 105Article in journal (Refereed) Published
Abstract [en]

This work aims at reviewing the present state of the art when it comes to understanding the pathophysiology of narcolepsy and the Kleine–Levin syndrome (KLS) from a neuroimaging point of view. This work also aims at discussing future perspectives of functional neuroimaging in these sleep disorders. We focus on functional magnetic resonance imaging (fMRI), which is a technique for in vivo measurements of brain activation in neuronal circuitries under healthy and pathological conditions. fMRI has significantly increased the knowledge on the affected neuronal circuitries in narcolepsy and the Kleine–Levin syndrome. It has been shown that narcolepsy is accompanied with disturbances of the emotional and the closely related reward systems. In the Kleine Levin syndrome, fMRI has identified hyperactivation of the thalamus as a potential biomarker that could be used in the diagnostic procedure. The fMRI findings in both narcolepsy and the Kleine–Levin syndrome are in line with previous structural and functional imaging studies. We conclude that fMRI in combination with multi-modal imaging can reveal important details about the pathophysiology in narcolepsy and the Kleine–Levin syndrome. In the future, fMRI possibly gives opportunities for diagnostic support and prediction of treatment response in individual patients.

Place, publisher, year, edition, pages
Switzerland: Frontiers Research Foundation , 2014. Vol. 5, no 105
Keyword [en]
functional magnetic resonance imaging, narcolepsy, hypersomnia, Kleine–Levin syndrome, sleep, ascending arousal system, hypothalamus, thalamus
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-109314DOI: 10.3389/fneur.2014.00105PubMedID: 25009530OAI: oai:DiVA.org:liu-109314DiVA: diva2:737310
Available from: 2014-08-12 Created: 2014-08-12 Last updated: 2017-12-05Bibliographically approved

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Engström, MariaKarlsson, ThomasLandtblom, Anne-Marie

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Engström, MariaKarlsson, ThomasLandtblom, Anne-Marie
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Division of Radiological SciencesFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Disability ResearchFaculty of Arts and SciencesDivision of NeuroscienceDepartment of NeurologyDepartment of Medical Specialist in Motala
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