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Design of large-scale manufacturing of induced pluripotent stem cell derived cardiomyocytes
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, The Institute of Technology. Loughborough University, UK.
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, The Institute of Technology.
2014 (English)In: Chemical engineering research & design, ISSN 0263-8762, E-ISSN 1744-3563, Vol. 92, no 6, 1142-1152 p.Article in journal (Refereed) Published
Abstract [en]

A new approach for design of large-scale manufacture of stem cell derived cells by using the biomechatronic methodology and computer-aided-design tools is described. The systematic conceptual design methodology for systems composed of active mechanical, electronic and biological components, here referred to as biomechatronics, is combined with the methodology for computer-aided design of bioprocesses. The objective has been to systematically investigate and compare by the combination of the methodologies what are favourable design alternatives in terms of equipment configuration and economic parameters. A demonstration case has been used for the manufacture of cardiomyocytes from human induced pluripotent stem cells. The results show how certain configurations are more favourable than others under given boundary conditions. The study indicates that the approach is possible to apply on other related bio-manufacturing systems.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 92, no 6, 1142-1152 p.
Keyword [en]
iPSC; CAD; Biomechatronics; Conceptual design; Pluripotent stem cells; Cardiomyocytes
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:liu:diva-109193DOI: 10.1016/j.cherd.2013.08.021ISI: 000337885300013OAI: oai:DiVA.org:liu-109193DiVA: diva2:737335
Available from: 2014-08-12 Created: 2014-08-11 Last updated: 2017-12-05Bibliographically approved

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Mandenius, Carl-Fredrik

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