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Environmentally induced epigenetic transgenerational inheritance of male infertility
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, The Institute of Technology. (Avian Behaviourial Genomics and Physiology Group)
Washington State University, Pullman, USA.
2014 (English)In: Current Opinion in Genetics and Development, ISSN 0959-437X, E-ISSN 1879-0380, Vol. 26, 79-88 p.Article in journal (Refereed) Published
Abstract [en]

Decreasing male fertility has been observed for the past fifty years. Examples of affected reproductive parameters include decreases in sperm count and sperm quality and increases in testicular cancer, cryptorchidism and hypospadias. Exposures to environmental toxicants during fetal development and early postnatal life have been shown to promote infertility. Environmental exposures inducing epigenetic changes related to male infertility range from life style, occupational exposures, environmental toxicants and nutrition. Exposures during fetal gonadal sex determination have been shown to alter the epigenetic programming of the germline that then can transmit this altered epigenetic information to subsequent generations in the absence of any exposures. This environmentally induced epigenetic transgenerational inheritance of disease will be a component of the etiology of male infertility.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 26, 79-88 p.
National Category
Biological Sciences
URN: urn:nbn:se:liu:diva-109350DOI: 10.1016/j.gde.2014.06.005ISI: 000345060800013PubMedID: 25104619OAI: diva2:737896
Available from: 2014-08-14 Created: 2014-08-14 Last updated: 2015-01-12Bibliographically approved

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Guerrero-Bosagna, Carlos
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