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Effects of Gadolinium Contrast Agent Administration on Automatic Brain Tissue Classification of Patients with Multiple Sclerosis
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology. Östergötlands Läns Landsting, Local Health Care Services in West Östergötland, Department of Medical Specialist in Motala.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Östergötlands Läns Landsting, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0001-8661-2232
2014 (English)In: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 35, no 7, 1330-1336 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE:

The administration of gadolinium contrast agent is a common part of MR imaging examinations in patients with MS. The presence of gadolinium may affect the outcome of automated tissue classification. The purpose of this study was to investigate the effects of the presence of gadolinium on the automatic segmentation in patients with MS by using the synthetic tissue-mapping method.

MATERIALS AND METHODS:

A cohort of 20 patients with clinically definite multiple sclerosis were recruited, and the T1 and T2 relaxation times and proton density were simultaneously quantified before and after the administration of gadolinium. Synthetic tissue-mapping was used to measure white matter, gray matter, CSF, brain parenchymal, and intracranial volumes. For comparison, 20 matched controls were measured twice, without gadolinium.

RESULTS:

No differences were observed for the control group between the 2 measurements. For the MS group, significant changes were observed pre- and post-gadolinium in intracranial volume (-13 mL, P < .005) and cerebrospinal fluid volume (-16 mL, P < .005) and the remaining, unclassified non-WM/GM/CSF tissue volume within the intracranial volume (+8 mL, P < .05). The changes in the patient group were much smaller than the differences, compared with the controls, which were -129 mL for WM volume, -22 mL for GM volume, +91 mL for CSF volume, 24 mL for the remaining, unclassified non-WM/GM/CSF tissue volume within the intracranial volume, and -126 mL for brain parenchymal volume. No significant differences were observed for linear regression values against age and Expanded Disability Status Scale.

CONCLUSIONS:

The administration of gadolinium contrast agent had a significant effect on automatic brain-tissue classification in patients with MS by using synthetic tissue-mapping. The observed differences, however, were much smaller than the group differences between MS and controls.

Place, publisher, year, edition, pages
American Society of Neuroradiology , 2014. Vol. 35, no 7, 1330-1336 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-109381DOI: 10.3174/ajnr.A3890ISI: 000339138200015PubMedID: 24699093OAI: oai:DiVA.org:liu-109381DiVA: diva2:738045
Available from: 2014-08-15 Created: 2014-08-15 Last updated: 2017-12-05Bibliographically approved

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Warntjes, Marcel Jan BertusTisell, AndersLandtblom, Anne-MarieLundberg, Peter

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Warntjes, Marcel Jan BertusTisell, AndersLandtblom, Anne-MarieLundberg, Peter
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Division of Cardiovascular MedicineFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in LinköpingDivision of Radiological SciencesDepartment of Radiation PhysicsDivision of NeuroscienceDepartment of NeurologyDepartment of Medical Specialist in MotalaDepartment of Radiology in Linköping
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American Journal of Neuroradiology
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