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Sublingual immunotherapy alters expression of IL-4 and its soluble and membrane-bound receptors
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. (CIMed, Centre for Individualised Medicine)
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping. (CIMed, Centre for Individualised Medicine)
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
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2014 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 69, no 11, 1564-1566 p.Article in journal (Refereed) Published
Abstract [en]

Seasonal allergic rhinitis (SAR) is a disease of increasing prevalence, which results from an inappropriate T-helper cell, type 2 (Th2) response to pollen. Specific immunotherapy (SIT) involves repeated treatment with small doses of pollen and can result in complete and lasting reversal of SAR. Here, we assayed the key Th2 cytokine, IL-4, and its soluble and membrane-bound receptor in SAR patients before and after SIT. Using allergen-challenge assays, we found that SIT treatment decreased IL-4 cytokine levels, as previously reported. We also observed a significant decrease in the IL-4 membrane-bound receptor (mIL4R) at both the level of mRNA and protein. SIT treatment resulted in a significant increase in the inhibitory soluble IL-4 receptor (sIL4R). Reciprocal changes in mIL4R and sIL4R were also observed in patient serum. Altered mIL4R and sIL4R is a novel explanation for the positive effects of immunotherapy with potential basic and clinical research implications.

Place, publisher, year, edition, pages
Wiley , 2014. Vol. 69, no 11, 1564-1566 p.
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Clinical Medicine Basic Medicine
Identifiers
URN: urn:nbn:se:liu:diva-109429DOI: 10.1111/all.12505ISI: 000343851200016PubMedID: 25130266OAI: oai:DiVA.org:liu-109429DiVA: diva2:738346
Available from: 2014-08-18 Created: 2014-08-18 Last updated: 2017-12-05

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Nestor, Colm EDadfa, ElhamErnerudh, JanGustafsson, MikaBjörkander, Jan FredrikBenson, MikaelZhang, Huan

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Nestor, Colm EDadfa, ElhamErnerudh, JanGustafsson, MikaBjörkander, Jan FredrikBenson, MikaelZhang, Huan
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in LinköpingDivision of Inflammation MedicineDepartment of Clinical Immunology and Transfusion MedicineAllergy Center
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Allergy. European Journal of Allergy and Clinical Immunology
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