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Electronic control of platelet adhesion using conducting polymer microarrays
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-2071-7768
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
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2014 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 14, no 16, 3043-3049 p.Article in journal (Refereed) Published
Abstract [en]

We hereby report a method to fabricate addressable micropatterns of e-surfaces based on the conducting polymer poly(3,4-ethylenedioxythiophene) doped with the anion tosylate (PEDOT:Tos) to gain dynamic control over the spatial distribution of platelets in vitro. With thin film processing and microfabrication techniques, patterns down to 10 mu m were produced to enable active regulation of platelet adhesion at high spatial resolution. Upon electronic addressing, both reduced and oxidized surfaces were created within the same device. This surface modulation dictates the conformation and/or orientation, rather than the concentration, of surface proteins, thus indirectly regulating the adhesion of platelets. The reduced electrode supported platelet adhesion, whereas the oxidized counterpart inhibited adhesion. PEDOT:Tos electrode fabrication is compatible with most of the classical patterning techniques used in printing as well as in the electronics industry. The first types of tools promise ultra-low-cost production of low-resolution (greater than30 mu m) electrode patterns that may combine with traditional substrates and dishes used in a classical analysis setup. Platelets play a pronounced role in cardiovascular diseases and have become an important drug target in order to prevent thrombosis. This clinical path has in turn generated a need for platelet function tests to monitor and assess platelet drug efficacy. The spatial control of platelet adherence presented here could prove valuable for blood cell separation or biosensor microarrays, e.g. in diagnostic applications where platelet function is evaluated.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2014. Vol. 14, no 16, 3043-3049 p.
National Category
Clinical Medicine Biological Sciences Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:liu:diva-109579DOI: 10.1039/c4lc00201fISI: 000339470400020PubMedID: 24960122OAI: oai:DiVA.org:liu-109579DiVA: diva2:739481
Available from: 2014-08-21 Created: 2014-08-21 Last updated: 2017-12-05

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Faxälv, LarsBolin, MariaJager, EdwinLindahl, TomasBerggren, Magnus

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Faxälv, LarsBolin, MariaJager, EdwinLindahl, TomasBerggren, Magnus
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Division of Microbiology and Molecular MedicineFaculty of Health SciencesDepartment of Clinical ChemistryDepartment of Science and TechnologyThe Institute of TechnologyBiosensors and BioelectronicsPhysics and Electronics
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Clinical MedicineBiological SciencesElectrical Engineering, Electronic Engineering, Information Engineering

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