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Apoptins: selective anticancer agents
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. Instituto de Biologia Molecular y Biotecnologia, La Paz, Bolivia.
Pomeranian Medical University, Szczecin, Poland.
University of Manitoba, Winnipeg, Canada.
Jagiellonian University, Krakow, Poland.
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2014 (English)In: Trends in Molecular Medicine, ISSN 1471-4914, E-ISSN 1471-499X, Vol. 20, no 9, 519-528 p.Article in journal (Refereed) Published
Abstract [en]

Therapies that selectively target cancer cells for deathhave been the center of intense research recently. Onepotential therapy may involve apoptin proteins, whichare able to induce apoptosis in cancer cells leavingnormal cells unharmed. Apoptin was originally discoveredin the Chicken anemia virus (CAV); however, humangyroviruses (HGyV) have recently been found that alsoharbor apoptin-like proteins. Although the cancer cellspecific activity of these apoptins appears to be wellconserved, the precise functions and mechanisms ofaction are yet to be fully elucidated. Strategies for bothdelivering apoptin to treat tumors and disseminating theprotein inside the tumor body are now being developed,and have shown promise in preclinical animal studies.

Place, publisher, year, edition, pages
2014. Vol. 20, no 9, 519-528 p.
Keyword [en]
anticancer agents; anaphase-promoting complex; CDK2; protein kinase C; protein phosphatase 2A.
National Category
Cell and Molecular Biology
URN: urn:nbn:se:liu:diva-109695DOI: 10.1016/j.molmed.2014.07.003ISI: 000342269500008PubMedID: 25164066OAI: diva2:740629
Available from: 2014-08-25 Created: 2014-08-25 Last updated: 2014-10-27Bibliographically approved

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Los, Marek Jan
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