liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Light-induced vibration in the hearing organ
Oregon Health and Science University, OR 97239 USA .
Oregon Health and Science University, OR 97239 USA .
University of Michigan, MI 48109 USA .
University of Michigan, MI 48109 USA.
Show others and affiliations
2014 (English)In: Scientific Reports, ISSN 2045-2322, Vol. 4, 5941- p.Article in journal (Refereed) Published
Abstract [en]

The exceptional sensitivity of mammalian hearing organs is attributed to an active process, where force produced by sensory cells boost sound-induced vibrations, making soft sounds audible. This process is thought to be local, with each section of the hearing organ capable of amplifying sound-evoked movement, and nearly instantaneous, since amplification can work for sounds at frequencies up to 100 kHz in some species. To test these fundamental precepts, we developed a method for focally stimulating the living hearing organ with light. Light pulses caused intense and highly damped mechanical responses followed by traveling waves that developed with considerable delay. The delayed response was identical to movements evoked by click-like sounds. This shows that the active process is neither local nor instantaneous, but requires mechanical waves traveling from the cochlear base toward its apex. A physiologically-based mathematical model shows that such waves engage the active process, enhancing hearing sensitivity.

Place, publisher, year, edition, pages
Nature Publishing Group: Open Access Journals - Option B / Nature Publishing Group , 2014. Vol. 4, 5941- p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-109872DOI: 10.1038/srep05941ISI: 000339941900001PubMedID: 25087606OAI: diva2:741629

Funding Agencies|NIH [DC-004554, DC-004084]; Swedish Research Council [K2011-63X-14061-11-39]; Research Council for Health, Working Life and Welfare [2006-1526]; Horselskadades Riksforbund; Tysta skolan foundation

Available from: 2014-08-28 Created: 2014-08-28 Last updated: 2014-09-02

Open Access in DiVA

fulltext(1469 kB)91 downloads
File information
File name FULLTEXT01.pdfFile size 1469 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Fridberger, Anders
By organisation
Division of Cell BiologyFaculty of Health Sciences
In the same journal
Scientific Reports
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 91 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 217 hits
ReferencesLink to record
Permanent link

Direct link