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Psychological stress in children may alter the immune response
School of Health Sciences, Department of Natural Science and Biomedicine, Jonköping University, Jönköping, Sweden, Division of Medical Diagnostics, Ryhov County Hospital, Jönköping, Sweden.
Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
School of Health Sciences, Department of Natural Science and Biomedicine, Jonköping University, Jönköping, Sweden, Division of Medical Diagnostics, Ryhov County Hospital, Jonköping, Sweden.
2014 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 192, no 5, 2071-2081 p.Article in journal (Refereed) Published
Abstract [en]

Psychological stress is a public health issue even in children and has been associated with a number of immunological diseases. The aim of this study was to examine the relationship between psychological stress and immune response in healthy children, with special focus on autoimmunity. In this study, psychological stress was based on a composite measure of stress in the family across the domains: 1) serious life events, 2) parenting stress, 3) lack of social support, and 4) parental worries. PBMCs, collected from 5-y-old high-stressed children (n = 26) and from 5-y-old children without high stress within the family (n = 52), from the All Babies In Southeast Sweden cohort, were stimulated with Ags (tetanus toxoid and b-lactoglobulin) and diabetes-related autoantigens (glutamic acid decarboxylase 65, insulin, heat shock protein 60, and tyrosine phosphatase). Immune markers (cytokines and chemokines), clinical parameters (C-peptide, proinsulin, glucose), and cortisol, as an indicator of stress, were analyzed. Children from families with high psychological stress showed a low spontaneous immune activity (IL-5, IL-10, IL-13, IL-17, CCL2, CCL3, and CXCL10; p less than 0.01) but an increased immune response to tetanus toxoid, b-lactoglobulin, and the autoantigens glutamic acid decarboxylase 65, heat shock protein 60, and tyrosine phosphatase (IL-5, IL-6, IL-10, IL-13, IL-17, IFN-g, TNF-A, CCL2, CCL3, and CXCL10; p less than 0.05). Children within the high-stress group showed high level of cortisol, but low level of C-peptide, compared with the control group (p less than 0.05). This supports the hypothesis that psychological stress may contribute to an imbalance in the immune response but also to a pathological effect on the insulin-producing b cells.Copyright © 2014 by The American Association of Immunologists.

Place, publisher, year, edition, pages
American Association of Immunologists , 2014. Vol. 192, no 5, 2071-2081 p.
National Category
Basic Medicine Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-110525DOI: 10.4049/jimmunol.1301713ISI: 000332701400011PubMedID: 24501202Scopus ID: 2-s2.0-84896524481OAI: oai:DiVA.org:liu-110525DiVA: diva2:748168
Note

Funding text:

This work was supported by the Swedish Research Council (Grant K2009-70X-21086-01-3), the Swedish Council for Working Life and Social Research (Grant 2008-0284), the Medical Research Council of Southeast Sweden, and the Swedish Child Diabetes Foundation.                           

Available from: 2014-09-18 Created: 2014-09-12 Last updated: 2017-12-05

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Frostell, AnneliLudvigsson, Johnny

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