liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Turbulence Quantification of Stenotic Blood Flow Using Image-Based CFD: Effect of Different Interventions
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology.ORCID iD: 0000-0003-4656-7662
Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, The Institute of Technology.ORCID iD: 0000-0003-1942-7699
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-5526-2399
2014 (English)In: WCB 2014, 2014Conference paper, Poster (Other academic)
Abstract [en]

Turbulent blood flow is often associated with some sort of cardiovascular disease, e.g. sharp bends and/or sudden constrictions/expansions of the vessel wall. The energy losses associated with the turbulent flow may increase the heart workload in order to maintain cardiac output (CO). In the present study, the amount of turbulent kinetic energy (TKE) developed in the vicinity of an aortic coarctation was estimated pre-intervention and in a variety of post-intervention configurations, using scale-resolved image-based computational fluid dynamics (CFD). TKE can be measured using magnet resonance imaging (MRI) and have also been validated with CFD simulations [1], i.e. a parameter that not only can be quantified using simulations but can also be measured by MRI.

Patient-specific geometry and inlet flow conditions were obtained using contrast-enhanced MR angiography and 2D cine phase-contrast MRI, respectively. The intervention procedure was mimicked using an inflation simulation, where six different geometries were obtained. A scale-resolving turbulence model, large eddy simulation (LES), was utilized to resolve the largest turbulent scales and also to capture the laminar-to-turbulent transition. All cases were simulated using baseline CO and with a 20% CO increase to simulate a possible flow adaption after intervention.

For this patient, results shows a non-linear decay of the total amount of TKE integrated over the cardiac phase as the stenotic cross-sectional area is increased by the intervention.  Figure 1 shows the original segmented geometry and two dilated coarctation with corresponding volume rendering of the TKE at peak systole. Due to turbulent transition at a kink upstream the stenosis further dilation of the coarctation tends to restrict the TKE to a plateau, and continued vessel expansion may therefore only induce unnecessary stresses onto the arterial wall. 

This patient-specific non-invasive framework has shown the geometrical impact on the TKE estimates. New insight in turbulence development indicates that the studied coarctation can only be improved to a certain extent, where focus should be on the upstream region, if further TKE reduction is motivated. The possibility of including MRI in a combined framework could have great potential for future intervention planning and follow-up studies.  

[1] J. Lantz, T. Ebbers, J. Engvall and M. Karlsson, Numerical and Experimental Assessment of Turbulent Kinetic Energy in an Aortic Coarctation, Journal of Biomechnics, 2013. 46(11): p. 1851-1858.

Place, publisher, year, edition, pages
Keyword [en]
Computational fluid dynamics, Large eddy simulation, Turbulent kinetic energy, Flow displacement, Non-Newtonian, Carreau, Virtual treatment, Magnetic resonance imaging
National Category
Fluid Mechanics and Acoustics
URN: urn:nbn:se:liu:diva-111042OAI: diva2:752749
7th World Congress of Biomechanics (WCB 2014), July 6-11, 2014, Boston, Massachusetts, USA
Available from: 2014-10-06 Created: 2014-10-06 Last updated: 2016-03-14

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Andersson, MagnusLantz, JonasKarlsson, Matts
By organisation
Applied Thermodynamics and Fluid MechanicsThe Institute of TechnologyMedia and Information TechnologyCenter for Medical Image Science and Visualization (CMIV)
Fluid Mechanics and Acoustics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 304 hits
ReferencesLink to record
Permanent link

Direct link