liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Trabecular bone histomorphometric measurements and contrast-to-noise ratio in CBCT
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Center for Diagnostics, Department of Radiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0002-7750-1917
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.
Karolinska University Hospital Huddinge, Stockholm, Sweden.
Show others and affiliations
2014 (English)In: Dento-Maxillo-Facial Radiology, ISSN 0250-832X, E-ISSN 1476-542X, Vol. 43, no 8, 20140196- p.Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim of this study was to evaluate how imaging parameters at clinical dental CBCT affect the accuracy in quantifying trabecular bone structures, contrast-to-noise ratio (CNR) and radiation dose.

Methods: 15 radius samples were examined using CBCT (Accuitomo FPD; J. Morita Mfg., Kyoto, Japan). Nine imaging protocols were used, differing in current, voltage, rotation degree, voxel size, imaging area and rotation time. Radiation doses were measured using a KAP-meter. After segmentation, six bone structure parameters and CNR were quantified. Micro-CT images with an isotropic resolution of 20 microns were used as a gold standard.

Results: Structure parameters obtained by CBCT were strongly correlated to those by micro CT, with correlation coefficients .0.90 for all studied parameters. Bone volume and trabecular thickness were not affected by changes in imaging parameters. Increased tube current from 5 to 8 mA, decreased isotropic voxel size from 125 to 80 microns and decreased rotation anglefrom 360° to 180° affected correlations for trabecular termini negatively. Decreasing rotation degree also weakened correlations for trabecular separation and trabecular number at 80 microns voxel size. Changes in the rotation degree and tube current affected CNR significantly. The radiation dose varied between 269 and 1284 mGy cm2.

Conclusions: Trabecular bone structure can be accurately quantified by clinical dental CBCT in vitro, and the obtained structure parameters are strongly related to those obtained by micro CT. A fair CNR and strong correlations can be obtained with a low radiation dose, indicating the possibility for monitoring trabecular bone structure also in vivo.

Place, publisher, year, edition, pages
British Institute of Radiology , 2014. Vol. 43, no 8, 20140196- p.
Keyword [en]
CBCT; micro-computed tomography; trabecular 7 bone; histomorphometry; bone segmentation; osteoporosis
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-111163DOI: 10.1259/dmfr.20140196ISI: 000346231400002PubMedID: 25168811OAI: oai:DiVA.org:liu-111163DiVA: diva2:754056
Available from: 2014-10-09 Created: 2014-10-09 Last updated: 2017-12-05Bibliographically approved
In thesis
1. Image Analysis for Trabecular Bone Properties on Cone-Beam CT Data
Open this publication in new window or tab >>Image Analysis for Trabecular Bone Properties on Cone-Beam CT Data
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Trabecular bone structure as well as bone mineral density (BMD) have impact on the biomechanical competence of bone. In osteoporosis-related fractures, there have been shown to exist disconnections in the trabecular network as well as low bone mineral density. Imaging of bone parameters is therefore of importance in detecting osteoporosis. One available imaging device is cone-beam computed tomography (CBCT). This device is often used in pre-operative imaging of dental implants, for which the trabecular network also has great importance.

Fourteen or 15 trabecular bone specimens from the radius were imaged for conducting this in vitro project.

The imaging data from one dual-energy X-ray absorptiometry (DXA), two multi-slice computed tomography (MSCT), one high-resolution peripheral quantitative computed tomography (HR-pQCT) and four CBCT devices were segmented using an in-house developed code based on homogeneity thresholding. Seven trabecular microarchitecture parameters, as well as two trabecular bone stiffness parameters, were computed from the segmented data. Measurements from micro-computed tomography (micro-CT) data of the same bone specimens were regarded as gold standard.

Correlations between MSCT and micro-CT data showed great variations, depending on device, imaging parameters and between the bone parameters. Only the bone-volume fraction (BV/TV) parameter was stable with strong correlations. Regarding both HR-pQCT and CBCT, the correlations to micro-CT were strong for bone structure parameters as well as bone stiffness parameters. The CBCT device 3D Accuitomo showed the strongest correlations, but overestimated BV/TV more than three times compared to micro-CT. The imaging protocol most often used in clinical imaging practice at our clinic demonstrated strong correlations as well as low radiation dose.

CBCT data of trabecular bone can be used for analysing trabecular bone properties, like bone microstructure and bone biomechanics, showing strong correlations to the reference method of micro-CT. The results depend on choice of CBCT device as well as segmentation method used. The in-house developed code based on homogeneity thresholding is appropriate for CBCT data. The overestimations of BV/TV must be considered when estimating bone properties in future clinical dental implant and osteoporosis research.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2017
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1594
National Category
Medical Image Processing
Identifiers
urn:nbn:se:liu:diva-142066 (URN)10.3384/diss.diva-142066 (DOI)9789176854341 (ISBN)
Public defence
2017-10-26, Hugo Theorell, Norra entrén, Campus US, Linköping, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2017-10-20 Created: 2017-10-20 Last updated: 2017-10-20Bibliographically approved

Open Access in DiVA

fulltext(2657 kB)212 downloads
File information
File name FULLTEXT02.pdfFile size 2657 kBChecksum SHA-512
c844ef7b90e74cf83a6bf28a812f01537e1c825217b0833351be774960fd8864eeb2593f794b2f565d67ce47d02ad1557e90c5321b58b2b4a67dfb63ef749b76
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Klintström, EvaSmedby, ÖrjanMoreno, Rodrigo

Search in DiVA

By author/editor
Klintström, EvaSmedby, ÖrjanMoreno, Rodrigo
By organisation
Division of Radiological SciencesFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Radiology in Linköping
In the same journal
Dento-Maxillo-Facial Radiology
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
Total: 212 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 268 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf