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Successful conversion to everolimus after cytomegalovirus infection in a heart transplant recipient
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
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2012 (English)In: International Heart Journal, ISSN 1349-2365, Vol. 53, no 3, 199-201 p.Article in journal (Refereed) Published
Abstract [en]

Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CM V infection, but is often associated with neutropenia, especially when used with mycophenolate mophetil (MMF). We experienced an HTx recipient with positive CMV antigenemia who suffered progressive neutropenia after administration of VGC. We switched MMF to everolimus (EVL) and assay for CM V antigenemia was constantly negative even after discontinuation of VGC. In all other 14 HTx recipients who received EVL for any reason, we found that assay for CMV antigenemia remained negative throughout the period of EVL administration. Considering the prophylactic effect on CMV, EVL can not only be an alternative to rescue from comorbidity, but might also be indicated earlier especially in CMV-seronegative HTx recipients. 

Place, publisher, year, edition, pages
International Heart Journal Association , 2012. Vol. 53, no 3, 199-201 p.
Keyword [en]
Heart transplantation; Cytomegalovirus; Everolimus; Neutropenia; Valganciclovir
National Category
Health Sciences
URN: urn:nbn:se:liu:diva-111198DOI: 10.1536/ihj.53.199ISI: 000307612800010PubMedID: 22790690OAI: diva2:754462
Available from: 2014-10-10 Created: 2014-10-10 Last updated: 2014-10-20Bibliographically approved

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Kato, Naoko
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