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Novel risk scoring system with preoperative objective parameters gives a good prediction of 1-year mortality in patients with a left ventricular assist device.
University of Tokyo, Japan.
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
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2012 (English)In: Circulation Journal, ISSN 1346-9843, E-ISSN 1347-4820, Vol. 76, no 8, 1895-1903 p.Article in journal (Refereed) Published
Abstract [en]


As we have previously reported, the preoperative profile defined by INTERMACS is a good predictor for the prognosis after left ventricular assist device (LVAD) implantation, but is largely dependent on the physician's decision. Several other risk stratification systems including objective parameters (eg, Leitz-Miller, Columbia, Seattle Heart Failure Model, APACHE II) have been proposed to estimate patient's mortality after LVAD implantation.


According to the preoperative data from 59 patients who received LVAD (10 implantable, 49 extracorporeal) since 2002 through 2010, we performed a logistic analysis and constructed a new scoring system (ie, the TODAI VAD score (TVAD score), assigning 8 points to serum albumin <3.2mg/dl (odds ratio [OR] 8.475), 7 points to serum total bilirubin >4.8mg/dl (OR 7.300), 6 points to left ventricular end-diastolic diameter <55mm (OR 5.917), 5 points to central venous pressure >11mmHg (OR 5.128)). The receiver-operating characteristic analysis showed that the area under the curve of our new scoring system (0.864) was significantly larger than any of the abovementioned 5 scoring methods (all P<0.05). With the TVAD score, low (0-8 points), intermediate (9-17 points), and high (18-26 points) risk strata had significantly different 1-year survival rates of 95%, 54%, and 14%, respectively (all P<0.001).


The TVAD score can predict the prognosis after LVAD implantation much better than the previously known methods.

Place, publisher, year, edition, pages
Japanese Circulation Society , 2012. Vol. 76, no 8, 1895-1903 p.
Keyword [en]
Continuous flow; Heart failure; Prognosis; Right ventricular dysfunction
National Category
Health Sciences
URN: urn:nbn:se:liu:diva-111195DOI: 10.1253/circj.CJ-12-0182ISI: 000306936900019PubMedID: 22664936OAI: diva2:754472

Funding Agencies|FUGAKU trust for medicinal research; Japan Society for the Promotion of Science [224943]; Japan Society for the Promotion of Science (JSPS) through its Funding Program for World-Leading Innovative RandD on Science and Technology (FIRST Program)

Available from: 2014-10-10 Created: 2014-10-10 Last updated: 2014-10-20Bibliographically approved

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Kato, Naoko
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