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Correction of hyponatremia by tolvaptan before left ventricular assist device implantation
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
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2012 (English)In: International Heart Journal, ISSN 1349-2365, E-ISSN 1349-3299, Vol. 53, no 6, 391-393 p.Article in journal (Refereed) Published
Abstract [en]

Hypervolemic hyponatremia is often complicated with advanced heart failure together with increased excretion of sodium by diuretics. Tolvaptan, an oral vasopressin-2-receptor antagonist, has been previously reported to improve congestion and correct hyponatremia through increased excretion of free water. However, there is little evidence concerning the administration of tolvaptan in patients with stage D heart failure. We experienced 2 patients with stage D heart failure who received 3.75 mg/day of tolvaptan to correct hyponatremia before ventricular assist device implantation. It may be useful, even for patients with stage D heart failure, to administer a low dose of tolvaptan to treat hyponatremia before ventricular assist device implantation to avoid a drastic alteration in serum sodium concentration perioperatively.

Place, publisher, year, edition, pages
International Heart Journal Association  , 2012. Vol. 53, no 6, 391-393 p.
Keyword [en]
Osmotic demyelination syndrome; Arginine vasopression; Heart failure
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-111193ISI: 000324451800011PubMedID: 23258142OAI: oai:DiVA.org:liu-111193DiVA: diva2:754482
Available from: 2014-10-10 Created: 2014-10-10 Last updated: 2017-12-05Bibliographically approved

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Kato, Naoko

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