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Bosentan improved persistent pulmonary hypertension in a case after implantation of a left ventricular assist device
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
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2013 (English)In: Journal of Artificial Organs, ISSN 1434-7229, E-ISSN 1619-0904, Vol. 16, no 1, 101-104 p.Article in journal (Refereed) Published
Abstract [en]

No medical treatment has been established to ameliorate pulmonary hypertension (PH) due to left heart disease. Heart transplantation (HTx) is thus far the definitive therapy for stage D heart failure, but concomitant PH is one of the major risk factors for death after HTx. Recently, implantation of a left ventricular assist device (LVAD) has been reported to improve PH and has become a major bridge tool for HTx. We experienced a rare case with persistent PH even after the implantation of a continuous-flow LVAD. The administration of an endothelin receptor antagonist, bosentan, significantly decreased pulmonary vascular resistance. Combination therapy with LVAD implantation and anti-PH medication may be useful for patients with stage D heart failure complicated with severe PH.

Place, publisher, year, edition, pages
Springer, 2013. Vol. 16, no 1, 101-104 p.
Keyword [en]
Out of proportion; Postcapillary; Endothelin receptor antagonist
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-111187DOI: 10.1007/s10047-012-0662-4ISI: 000316359400013PubMedID: 23015200OAI: oai:DiVA.org:liu-111187DiVA: diva2:754512
Available from: 2014-10-10 Created: 2014-10-10 Last updated: 2017-12-05Bibliographically approved

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Kato, Naoko

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