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Pertussis-Specific Memory B-Cell and Humoral IgG Responses in Adolescents after a Fifth Consecutive Dose of Acellular Pertussis Vaccine
Public Health Agency Sweden, Sweden; Karolinska Institute, Sweden.
Public Health Agency Sweden, Sweden.
Public Health Agency Sweden, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
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2014 (English)In: Clinical and Vaccine Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 21, no 9, 1301-1308 p.Article in journal (Refereed) Published
Abstract [en]

In order to impede the increase in pertussis incidence in the adolescent group, a school-leaving booster dose administered at the age of 14 to 16 years will be introduced in Sweden in 2016. Preceding this introduction, an open-label, randomized, multicenter, clinical trial without a control group and with blinded analysis was performed, investigating both safety and immunogenicity. Reported here are the memory B-cell and serological responses detected in a smaller cohort (n = 34) of the 230 subjects recruited to the study. All subjects had received primary vaccination consisting of three doses of diphtheria-tetanus-5-component pertussis (DTaP5) vaccine, at 3, 5, and 12 months of age, and a tetanus-low-dose diphtheria-5-component pertussis (Tdap5) vaccine booster at 5.5 years. In this study, the subjects were randomly assigned and received either a Tdap1 or Tdap5 booster. Of the 230 participants, 34 subjects had samples available for evaluation of IgG-producing memory B-cell responses. Both vaccine groups had significant increases in pertussis toxin-specific serum IgG levels, but only the 1-component group showed significant increases in pertussis toxin-specific memory B cells. The 5-component group had significant increases in filamentous hemagglutinin- and pertactin-specific memory B-cell and serum IgG levels; these were not seen in the 1-component group, as expected. In conclusion, this study shows that a 5th consecutive dose of an acellular pertussis vaccine induces B-cell responses in vaccinated adolescents.

Place, publisher, year, edition, pages
American Society for Microbiology , 2014. Vol. 21, no 9, 1301-1308 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-111261DOI: 10.1128/CVI.00280-14ISI: 000341624800015PubMedID: 25008903OAI: oai:DiVA.org:liu-111261DiVA: diva2:755594
Note

Funding Agencies|Statens Serum Institute; Sanofi Pasteur MSD (Sweden)

Available from: 2014-10-15 Created: 2014-10-14 Last updated: 2017-10-31

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Jenmalm, MariaNilsson, Lennart

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