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Atypical femoral fractures, bisphosphonates, and mechanical stress
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
2014 (English)In: Current osteoporosis reports, ISSN 1544-1873, Vol. 12, no 2, 189-193 p.Article in journal (Refereed) Published
Abstract [en]

Atypical fractures are stress fractures occurring in the femoral shaft and closely related to bisphosphonate use. We here discuss their radiographic definition and different putative etiologies, apart from mechanical stress. Long time reduction of skeletal remodeling because of bisphosphonate use is thought to allow time for the bone to deteriorate mechanically, resulting in reduced toughness. However, the risk of atypical fracture diminishes rapidly after cessation of treatment, which suggests more acute effects of bisphosphonate use. Microdamage normally accumulates at areas of high stress. Possibly, ongoing bisphosphonate use reduces the ability to resorb and replace areas of microdamage by targeted remodeling. This could lead to crack propagation beyond a point of no return, ending in macroscopic stress fracture.

Place, publisher, year, edition, pages
Springer, 2014. Vol. 12, no 2, 189-193 p.
Keyword [en]
Atypical femoral fractures, Bisphosphonates, Bone remodeling, Osteoporosis, Bone fragility
National Category
Orthopedics
Identifiers
URN: urn:nbn:se:liu:diva-111392DOI: 10.1007/s11914-014-0200-9ISI: 000347283600007PubMedID: 24615358OAI: oai:DiVA.org:liu-111392DiVA: diva2:756099
Available from: 2014-10-16 Created: 2014-10-16 Last updated: 2016-07-01Bibliographically approved

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Aspenberg, PerSchilcher, Jörg

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Division of Clinical SciencesFaculty of Health SciencesDepartment of Orthopaedics in Linköping
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
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  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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