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Assessment of the microcirculation using combined model based diffuse reflectance spectroscopy and laser Doppler flowmetry
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.ORCID iD: 0000-0003-4377-8544
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. Perimed AB, Järfälla-Stockholm, Sweden .ORCID iD: 0000-0002-3454-6576
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-6385-6760
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
2015 (English)In: 16th Nordic-Baltic Conference on Biomedical Engineering: 16. NBC & 10. MTD 2014 joint conferences. October 14-16, 2014, Gothenburg, Sweden, Springer, 2015, 52-54 p.Conference paper, Published paper (Refereed)
Abstract [en]

By using a combined inverse model for diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF) the tissue fraction of red blood cells (RBCs), their oxygenation and speed-resolved perfusion are estimated in absolute units. DRS spectra (450 to 850 nm) are measured at two source-detector distances; 0.4 and 1.2 mm. LDF spectra are measured at 1.2 mm, integrated in the same fiber-optic probe. Inverse Monte Carlo technique and an adaptive tissue model is used to quantify the microcirculatory parameters. Measurements were done during venous occlusion of the tissue. The model fitting yields a good spectral fit for the two DRS spectra and the LDF spectrum. The physiological responses regarding for example which speed regions respond to provocations follows a priori expectations. The combined model gives quantitative measures of RBC tissue fraction, oxygenation and speed resolved perfusion from the same sampling volume which gives new opportunities to interpret data.

Place, publisher, year, edition, pages
Springer, 2015. 52-54 p.
Series
IFMBE Proceedings, ISSN 1680-0737 ; 48
Keyword [en]
diffuse reflectance spectroscopy, laser Doppler flowmetry, modeling, Monte Carlo simulations
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-111403DOI: 10.1007/978-3-319-12967-9_14ISI: 000347893000014ISBN: 978-3-319-12966-2 (print)ISBN: 978-3-319-12967-9 (print)OAI: oai:DiVA.org:liu-111403DiVA: diva2:756182
Conference
16th Nordic Baltic Conference on Biomedical Engineering, October 14-16, 2014, Gothenburg, Sweden
Available from: 2014-10-16 Created: 2014-10-16 Last updated: 2016-08-31Bibliographically approved

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Jonasson, HannaFredriksson, IngemarLarsson, MarcusStrömberg, Tomas

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