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Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury
Rockefeller University, NY 10065 USA.
Rockefeller University, NY 10065 USA.
Rockefeller University, NY 10065 USA.
Rockefeller University, NY 10065 USA.
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2014 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 273, 123-132 p.Article in journal (Refereed) Published
Abstract [en]

We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finally, an extensive examination of mouse behavioral capacities, looking for deficits in this model of TBI, suggest that the strongest effects of TBI in this model are found in the initiation of any kind of movement.

Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 273, 123-132 p.
Keyword [en]
Deep brain stimulation; Traumatic brain injury; Generalized arousal; Mouse; Central thalamus
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-111595DOI: 10.1016/j.bbr.2014.07.026ISI: 000342256300015PubMedID: 25072520OAI: oai:DiVA.org:liu-111595DiVA: diva2:758597
Note

Funding Agencies|NIH [5R01 NS067249]

Available from: 2014-10-27 Created: 2014-10-27 Last updated: 2017-12-05

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