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Familias 3-Extensions and new functionality
Norwegian Institute Public Heatlh, Norway; Norwegian University of Life Science, Norway.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden.
Norwegian University of Life Science, Norway; Norwegian Institute Public Heatlh, Norway.
2014 (English)In: Forensic Science International: Genetics, ISSN 1872-4973, E-ISSN 1878-0326, Vol. 13, 121-127 p.Article in journal (Refereed) Published
Abstract [en]

In relationship testing the aim is to determine the most probable pedigree structure given genetic marker data for a set of persons. Disaster Victim Identification (DVI) based on DNA data from presumed relatives of the missing persons can be considered to be a collection of relationship problems. Forensic calculations in investigative mode address questions like "How many markers and reference persons are needed? Such questions can be answered by simulations. Mutations, deviations from Hardy-Weinberg Equilibrium (or more generally, accounting for population substructure) and silent alleles cannot be ignored when evaluating forensic evidence in case work. With the advent of new markers, so called microvariants have become more common. Previous mutation models are no longer appropriate and a new model is proposed. This paper describes methods designed to deal with DVI problems and a new simulation model to study distribution of likelihoods. There are softwares available, addressing similar problems. However, for some problems including DVI, we are not aware of freely available validated software. The Familias software has long been widely used by forensic laboratories worldwide to compute likelihoods in relationship scenarios, though previous versions have lacked desired functionality, such as the above mentioned. The extensions as well as some other novel features have been implemented in the new version, freely available at www.familias.no. The implementation and validation are briefly mentioned leaving complete details to Supplementary sections.

Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 13, 121-127 p.
Keyword [en]
Familias; Paternity; Likelihood computations; Simulation; Mutation; Disaster victim identification
National Category
Other Medical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-111592DOI: 10.1016/j.fsigen.2014.07.004ISI: 000342444400025PubMedID: 25113576OAI: oai:DiVA.org:liu-111592DiVA: diva2:758609
Note

Funding Agencies|European Union [285487]

Available from: 2014-10-27 Created: 2014-10-27 Last updated: 2017-12-05

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Tillmar, Andreas O.

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