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Alzheimer and platelets: Low-density platelet populations reveal increased serotonin content in Alzheimer type dementia
Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
Östergötlands Läns Landsting, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
Karolinska Institute, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in East Östergötland, Primary Health Care in Norrköping.
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2014 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 47, no 15, 51-53 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Alzheimers disease (AD) is a progressive form of dementia characterized by an increase in the toxic substance beta-amyloid in the brain. Platelets display a substantial heterogeneity with respect to density. They further contain a substantial amount of beta-amyloid precursor protein. Platelets take up and store serotonin (5-HT) that plays an important role in the pathogenesis of severe depression. The current study aims to investigate platelet serotonin content in different platelet density populations. Material and methods: The study involved 8 patients (age 70 +/- 8 (SD) years) (3 females/5 males) with moderate AD. 6 healthy elderly subjects (age 66 +/- 9 (SD) years) (3 females/3 males) served as controls. The platelet population was divided into 17 subpopulations according to density, using a linear Percoll (TM) gradient. Platelets were counted in all fractions. After cell lysis an ELISA technique was employed to determine the 5-HT content in each platelet subfraction. Results: The two study groups did not differ significantly regarding platelet distribution in the gradients, but AD sufferers have a significantly higher 5-HT content (p less than 0.05) in the lighter platelet populations. Discussion: AD-type dementia proved to be associated with lighter platelets containing more 5-HT. It is possible that platelets from AD patients release less 5-HT. It is speculated that AD synapses are affected in a manner comparable to platelets, which could explain why 5-HT reuptake inhibitors are less effective in AD dementia.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 47, no 15, 51-53 p.
Keyword [en]
Alzheimers disease; Fibrinogen; Platelets; Platelet activity; Platelet density; Platelet heterogeneity; Serotonin
National Category
Basic Medicine Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-111746DOI: 10.1016/j.clinbiochem.2014.07.007ISI: 000342822100008PubMedID: 25041722OAI: oai:DiVA.org:liu-111746DiVA: diva2:759794
Note

Funding Agencies|Ahlens Foundation; Gun and Bertil Stohnes Foundation; Magnus Bergvalls Foundation; "Stiftelsen for Gamla Tjanarinnor"; Swedish Alzheimer Foundation; Swedish Board for Health and Welfare; Pfizer AB, Sweden

Available from: 2014-10-31 Created: 2014-10-31 Last updated: 2017-12-05Bibliographically approved

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Milovanovic, MichaNilsson, StaffanLindahl, TomasPost, ClaesJäremo, Petter

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Milovanovic, MichaNilsson, StaffanLindahl, TomasPost, ClaesJäremo, Petter
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Division of Health, Activity and CareFaculty of Health SciencesDepartment of Internal Medicine in NorrköpingDivision of Community MedicinePrimary Health Care in NorrköpingDivision of Microbiology and Molecular MedicineDepartment of Clinical ChemistryDivision of Cell BiologyDepartment of Medical and Health Sciences
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