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Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Physics. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-1639-5735
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.ORCID iD: 0000-0003-4075-159X
2014 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 42, 1460-1464 p.Article in journal (Refereed) Published
Abstract [en]

Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes to the cytosol accompanies apoptosis signalling in several systems. The regulatory mechanism of lysosomal stability is, however, poorly understood. Lipophilic or amphiphilic compounds with a basic moiety will become protonated and trapped within lysosomes, and such lysosomotropic behaviour is also found in many pharmacological drugs. The natural sphingolipid sphingosine exhibits lysosomotropic detergent ability and is an endogenous candidate for controlling lysosomal membrane permeabilization. The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery system in the future. The present review summarizes the current knowledge on the targeting and permeabilizing properties of lysosomotropic detergents from a cellular and physicochemical perspective.

Place, publisher, year, edition, pages
Portland Press , 2014. Vol. 42, 1460-1464 p.
Keyword [en]
detergent; lysosome; lysosomal membrane; O-methyl-serine dodecylamine hydrochloride (MSDH); permeabilization; sphingosine
National Category
Chemical Sciences Physical Sciences Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-111745DOI: 10.1042/BST20140145ISI: 000342566700032PubMedID: 25233432OAI: oai:DiVA.org:liu-111745DiVA: diva2:759796
Note

Funding Agencies|Swedish Research Council [3214]; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse

Available from: 2014-10-31 Created: 2014-10-31 Last updated: 2017-12-05

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Villamil Giraldo, Ana M.Appelqvist, HannaEderth, ThomasÖllinger, Karin

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