liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Fatal intoxications associated with the designer opioid AH-7921
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences. National Board of Forensic Medicine, Linköping, Sweden.
National Board of Forensic Medicine, Linköping, Sweden.
National Board of Forensic Medicine, Linköping, Sweden.
National Board of Forensic Medicine, Linköping, Sweden.
Show others and affiliations
2014 (English)In: Journal of Analytical Toxicology, ISSN 0146-4760, Vol. 38, no 8, 599-604 p.Article in journal (Refereed) Published
Abstract [en]

AH-7921 (3,4-dichloro-N-[(1-dimethylamino) cyclohexylmethyl] benzamide) is a designer opioid with similar to 80% of morphines m-agonist activity. Over a 6-month period, we encountered nine deaths where AH-7921 was involved and detected in blood from the deceased. Shortly after the last death, on August 1 2013, AH-7921 was scheduled as a narcotic and largely disappeared from the illicit market in Sweden. AH-7921 was measured by a selective liquid chromatography- MS-MS method and the concentrations of AH-7921 ranged from 0.03 to 0.99 mu g/g blood. Six of our cases had other drugs of abuse on board and most had other medications such as benzodiazepines, antidepressants and analgesics. However, the other medicinal drugs encountered were present in postmortem therapeutic concentrations and unlikely to have contributed to death. In addition to the parent compound, we identified six possible metabolites where two N-demethylated dominated and four mono-hydroxylated were found in trace amounts in the blood. In conclusion, deaths with AH-7921 seem to occur both at low and high concentrations, probably a result of different tolerance to the drug. Hence, it is reasonable to assume that no sharp dividing line exists between lethal and non-lethal concentrations. Further, poly-drug use did not seem to be a major contributing factor for the fatal outcome.

Place, publisher, year, edition, pages
Oxford University Press, 2014. Vol. 38, no 8, 599-604 p.
National Category
Basic Medicine
URN: urn:nbn:se:liu:diva-112182DOI: 10.1093/jat/bku057ISI: 000343324100022PubMedID: 25217553OAI: diva2:764231
Available from: 2014-11-18 Created: 2014-11-18 Last updated: 2014-11-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kronstrand, RobertKugelberg, Fredrik
By organisation
Division of Drug ResearchFaculty of Health Sciences
In the same journal
Journal of Analytical Toxicology
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 69 hits
ReferencesLink to record
Permanent link

Direct link