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Age, prognostic impact of QRS prolongation and left bundle branch block, and utilization of cardiac resynchronization therapy: findings from 14713 patients in the Swedish Heart Failure Registry
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Karolinska Institute, Sweden.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
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2014 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 16, no 10, 1073-1081 p.Article in journal (Refereed) Published
Abstract [en]

AimsAge is not a contraindication to cardiac resynchronization therapy (CRT), but the prevalence and prognostic impact of QRS prolongation with intraventricular conduction delay (IVCD) and left bundle branch block (LBBB), as well as CRT utilization, may differ with age. We tested the hypotheses that in the elderly: (i) IVCD and LBBB are more prevalent, (ii) IVCD and LBBB are more harmful, and (iii) CRT is underutilized. Methods and resultsWe studied 14713 patients with ejection fraction 39% in the Swedish Heart Failure Registry and divided into age groups 65years, 66-80years and greater than80years. Among 13782 patients without CRT, IVCD was present in the three age groups in 11% vs. 15% vs. 19% and LBBB was present in 20% vs. 27% vs. 28%, respectively, (Pless than0.001). The multivariable hazard ratio (HR) for all-cause mortality over a median (interquartile range) follow-up of 29 (12-53) months for IVCD vs. narrow QRS was 1.31 (1.06-1.63, P=0.013) in the 65year group, 1.32 (1.17-1.47, Pless than0.001) in the 66-80year group, and 1.26 (1.21-1.41, pless than0.001) in the greater than80year group. For LBBB vs. narrow QRS it was 1.29 (1.07-1.56, P=0.009), 1.17 (1.06-1.30, P=0.002), and 1.10 (0.99-1.22, P=0.091), respectively. The adjusted P for interaction between age and QRS morphology was 0.664. In the three age groups, CRT was present in 6% vs. 8% vs. 4% and absent but with indication in 23% vs. 32% vs. 37%, respectively (Pless than0.001). ConclusionsBoth IVCD and LBBB were more common with increasing age and were similarly strong independent predictors of mortality and in all ages. The underutilization of CRT was worse with increasing age.

Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy B / Wiley , 2014. Vol. 16, no 10, 1073-1081 p.
Keyword [en]
Age; Heart Failure; QRS width; Left bundle branch block; Intraventricular conduction delay; Epidemiology; Cardiac resynchronization therapy
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-112312DOI: 10.1002/ejhf.162ISI: 000343757300005PubMedID: 25201219OAI: oai:DiVA.org:liu-112312DiVA: diva2:765595
Note

Funding Agencies|Boston Scientific; Swedish Research Council [2013-23897-104604-23]; Swedish Heart Lung Foundation [20080409, 20100419, 20080498, 20110406, 20090870]; Stockholm County Council [20090556, 20110120, 20090376, 20110610]

Available from: 2014-11-24 Created: 2014-11-24 Last updated: 2017-12-05

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Dahlström, Ulf

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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Cardiology in Linköping
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